Apolipoprotein M promotes proliferation and invasion in non-small cell lung cancers via upregulating S1PR1 and activating the ERK1/2 and PI3K/AKT signaling pathways

Biochemical and Biophysical Research Communications
Yifei ZhuXiao-ying Zhang

Abstract

Apolipoprotein M (ApoM) is a sphingosine 1-phosphate (S1P) carrier involved in the regulation of S1P. Signaling pathways involving sphingosine kinases (SphKs) and S1P-S1P receptors (S1PRs) play important roles in the oncogenesis of multiple cancers including non-small cell lung cancer (NSCLC). In the present study we have clarified the potential roles of ApoM on the oncogenesis process of NSCLC cells. We detected the ApoM expression in NSCLC tissues and further analyzed its clinical significance. Moreover, we determined effects of ApoM overexpression on tumor cellular behaviours of NSCLC in vitro and in vivo. Our results demonstrated that ApoM protein mass were clearly higher in the NSCLC tissues than in non-NSCLS tissues. Overexpression of ApoM could promote NSCLC cell proliferation and invasion in vitro and tumor growth in vivo, which might be via upregulating S1PR1 and activating the ERK1/2 and PI3K/AKT signaling pathways. It is concluded that up-regulation of ApoM in NSCLC might be associated with the tumor induced inflammation and tumor microenvironment as well as promoting oncogenesis of NSCLC. Further study needs to elucidate the underlying mechanisms.

Citations

May 23, 2019·Molecular Diagnosis & Therapy·Narges RostamiFarhad Jadidi-Niaragh
Oct 2, 2019·Cancer Medicine·Liwen RenGuanhua Du
Nov 9, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Shuang YaoGuanghua Luo
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Aug 24, 2019·Journal of Experimental & Clinical Cancer Research : CR·Yan LiuGuichun Huang
Apr 20, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y Zhou, G Luo
Nov 12, 2020·Scientific Reports·Haixiang XueJisheng Liu
May 20, 2021·Journal of Receptor and Signal Transduction Research·Gangli Cheng, Lu Zheng

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