Apolipoprotein(a) isoforms in infarcted men under 60 years old

Clinical Biochemistry
Pilar CalmarzaJuan Carlos Vella

Abstract

The aim of this study was to compare the Lp(a) concentration and the frequency distribution of the apo(a) isoforms of a myocardial infarcted male group under 60 years old and a group of healthy subjects (controls). A total of 111 infarcted men and 99 men free from disease were enrolled in this study. Lp(a) concentrations were measured by a commercial available rate nephelometry method, and apolipoprotein(a) isoform analysis was performed by sodium dodecyl sulfate (SDS) polyacrilamide gel electrophoresis (PAGE) and immunoblotting. Infarcted patients had higher Lp(a) concentrations (0.33 +/- 0.36 g/l) than noninfarcted subjects did (0.19 +/- 0.22 g/l), and these differences were significant (P = 0.001). Infarcted patients have also shown a greater proportion of elevated (> or = 0.30 g/l) Lp(a) concentrations 37.8% than controls 20.2% (P < 0.01). The distributions of apo(a) phenotypes for patients with myocardial infarction and controls were remarkably different (P < 0.001), and the proportions of smaller isoforms were significantly different by chi-square analysis (P < 0.01). Infarcted patients under 60 years old display higher Lp(a) concentrations and a significantly higher proportion of low molecular weight apolipoprotein(a) is...Continue Reading

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Citations

Feb 13, 2007·Clinical Biochemistry·Mirjana BećarevićNada Majkić-Singh
May 8, 2010·Journal of the American College of Cardiology·Sebhat ErqouJohn Danesh
Sep 15, 2011·European Journal of Preventive Cardiology·P CalmarzaP Lopez
Nov 3, 2016·Journal of Lipid Research·Børge G Nordestgaard, Anne Langsted

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