PMID: 2116785Aug 1, 1990Paper

Apolipoproteins A-I and B as predictors of angiographically defined coronary artery disease

Archives of Internal Medicine
R A ReinhartS K Broste

Abstract

Apolipoprotein A-I and B concentrations were measured in 502 patients undergoing diagnostic cardiac catheterization to assess the predictive power of apolipoproteins B and A-I to discriminate between patients with coronary artery disease and those with normal coronary arteries as defined by coronary arteriography. The strength of the associations was compared with that of the associations between traditional risk factors (eg, smoking status, cholesterol levels) and coronary artery disease. The study population consisted of 154 women (mean age, 62.9 years) and 348 men (mean age, 59.6 years). The apolipoprotein A-I concentration averaged (+/- SD) 124 +/- 25 mg/dL and the apolipoprotein B concentration, 98 +/- 24 mg/dL. In all cases, the apolipoprotein measures showed a larger univariate difference between the "normal" (no coronary artery disease) group (66 patients) and the group with coronary artery disease (436 patients) than did the corresponding standard lipoprotein measures. The variable with the strongest association with coronary artery disease was the ratio of apolipoprotein A-I to apolipoprotein B, followed by apolipoprotein B level. These findings were confirmed using logistic regression, adjusting for other coronary ar...Continue Reading

Citations

Jun 3, 2011·Journal of Translational Medicine·Pavel MájekJan E Dyr
Aug 2, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Mehdi RasouliVahid Mokhberi
May 15, 1992·The American Journal of Cardiology·G SigurdssonN Sigfusson
Oct 25, 2006·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Margo DenkeAndrew M Tershakovec
Feb 1, 1994·Angiology·C AlessandriC Cordova
Jul 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·H T WesterveldD W Erkelens
Jan 1, 1992·International Journal of Clinical & Laboratory Research·I JungnerE Steiner

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