Apolipoproteins as markers and managers of coronary risk

QJM : Monthly Journal of the Association of Physicians
D C Chan, G F Watts

Abstract

Coronary artery disease (CAD) is a major cause of morbidity and mortality in Western communities. Reliable indices of coronary risk assessment and targets for drug treatment are important to the management of patients. Although plasma LDL cholesterol is well established as a predictor of CAD, it may not be the best circulatory marker. Results from recent epidemiological studies and statin trials suggest that apolipoprotein B-100 (apoB), with or without apoA-I, is superior to LDL cholesterol in predicting coronary events. Measurements of apolipoproteins are internationally standardized, automated, cost-effective and more convenient and precise than those for LDL cholesterol. ApoB may also be preferable to the measurement of non-HDL cholesterol. Measurement of apolipoproteins (apoB and possibly apoA-I) should be routinely added to the routine lipid profile (cholesterol, triglycerides and high-density lipoprotein cholesterol) to assess the atherogenic potential of lipid disorders. This is particularly relevant to dyslipidaemias characterized by an elevation in plasma triglycerides. Apolipoproteins, especially apoB, could also replace the standard "lipid profile" as a target for therapy in at-risk patients.

Citations

Apr 8, 2011·Age·Mónica Santos-GonzálezJosé M Villalba
Jan 5, 2008·Current Atherosclerosis Reports·Allan D Sniderman, Robert S Kiss
May 21, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Dick C ChanGerald F Watts
Nov 23, 2012·Genetic Testing and Molecular Biomarkers·Chetana S DeshpandeManjari S Mukherjee
Oct 18, 2011·The Clinical Journal of Pain·Maaike DirckxFrank J P M Huygen
Feb 19, 2008·Current Opinion in Rheumatology·Hartmut Michels, Eugen Mengel
Feb 16, 2011·Journal of Clinical Neuromuscular Disease·Paul D Morte, Larry M Magee
Jul 16, 2009·Menopause : the Journal of the North American Menopause Society·Pauliina TuomikoskiOlavi Ylikorkala
Apr 15, 2008·Current Opinion in Nephrology and Hypertension·Kellie Hunter Campbell, Ann M O'Hare
Dec 7, 2011·Journal of Gastroenterology and Hepatology·Jenni HyysaloHannele Yki-Järvinen
Jul 17, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Belinda ElishaRémi Rabasa-Lhoret
May 22, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Iffat RahmanPatrik K E Magnusson
Jul 1, 2010·Ayu·Manjiri Arun NadkarniB Ravishankar
Jan 18, 2007·Expert Opinion on Therapeutic Targets·John R Burnett, Gerald F Watts
May 7, 2010·Climacteric : the Journal of the International Menopause Society·P TuomikoskiO Ylikorkala
Jan 25, 2011·Annals of Medicine·Pauliina TuomikoskiTomi S Mikkola
Dec 30, 2015·Journal of Sports Sciences·Luiz Gustavo Marin EmedJosé Rocha Faria-Neto
Jul 17, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Göran Walldius, Ingmar Jungner
May 20, 2014·Biological Reviews of the Cambridge Philosophical Society·Chen-Lu WuBi-Lian Yu
Sep 15, 2010·Molecular Aspects of Medicine·Mar LarrosaFrancisco A Tomás-Barberán
Jun 6, 2009·Pharmacology & Therapeutics·Gerald F WattsDick C Chan
Feb 2, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rabia JohnsonJohan Louw
Nov 6, 2008·Journal of Child Neurology·Hoda Yahya TomoumAhmed Hanafy Ali
Jun 9, 2007·Current Opinion in Cardiology·Göran Walldius, Ingmar Jungner
Oct 2, 2019·Cancer Medicine·Liwen RenGuanhua Du
Apr 30, 2008·Clinical Chemistry·John R Burnett, Gerald F Watts
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Allan D Sniderman
Jan 1, 2011·The Journal of Cardiovascular Nursing·Debra A Robbins
Oct 5, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rachel DanknerAngela Chetrit
Jan 1, 2014·BMC Obesity·Jean-Patrice BaillargeonMarie-France Langlois
Jan 16, 2016·Clinical and Experimental Nephrology·Daniela Lemos BorgesSebastião Rodrigues Ferreira Filho
Oct 22, 2016·The International Journal of Cardiovascular Imaging·Ana Claudia Gomes Pereira PetiscoAmanda Guerra de Moraes Rego Sousa
Jul 27, 2017·Canadian Journal of Physiology and Pharmacology·Vikrant Rai, Devendra K Agrawal
Nov 30, 2019·Advances in Nutrition·Antwi-Boasiako Oteng, Sander Kersten
May 1, 2021·International Journal of Molecular Sciences·Eva Maria SturmGunther Marsche
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.