Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's beta-amyloid peptide in cultured vascular smooth muscle cells

Brain Research
B Mazur-KoleckaH M Wisniewski

Abstract

Cultured brain vascular smooth muscle cells (SMCs) accumulate beta-peptide in intracytoplasmic granules [9,10,33]. We show here that apoE3 and E4 induces the intracytoplasmic beta-peptide accumulation in cultured human and canine SMCs. The induction is dose-dependent and the accumulated granules also contain apoE and some were thioflavine S-positive. The deposits induced with apoE3 were more abundant though less stable than with apoE4. Transthyretin at physiological concentrations blocked the effects of apoE3/E4. Thus, accumulation of beta-peptide appears to be regulated by beta-peptide carrier proteins.

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Citations

Feb 28, 2004·Brain Research·Janusz FrackowiakBozena Mazur-Kolecka
Apr 25, 2003·Experimental and Molecular Pathology·Ilene D AuerbachHarry V Vinters
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
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Jul 5, 2005·Neurobiology of Aging·Bozena Mazur-KoleckaJanusz Frackowiak
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Jul 2, 2003·Journal of Neuropathology and Experimental Neurology·Janusz FrackowiakBozena Mazur-Kolecka
May 15, 2019·Journal of Clinical Medicine·Karan GovindpaniAndrea Kwakowsky
Feb 18, 2005·Journal of Neuropathology and Experimental Neurology·Janusz FrackowiakBozena Mazur-Kolecka
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Jul 14, 2006·Neurobiology of Aging·Arlene M ManelliMary Jo LaDu

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