PMID: 6538046Jan 1, 1984Paper

Apomorphine effects on behavioral response to ethanol in mice selectively bred for differential sensitivity to ethanol

Pharmacology, Biochemistry, and Behavior
B C DudekT J Phillips

Abstract

Two lines of mice selectively bred for differences in response to a hypnotic dose of ethanol were administered apomorphine alone or in combination with ethanol. When administered by itself, apomorphine produced similar dose-dependent depression of locomotor activity and increases in stereotypy in the two lines. Doses of apomorphine (0.5 microM/kg and 2 microM/kg) thought to bind only presynaptic dopamine receptors blocked the slight locomotor activation to 1.5 g/kg ethanol in the ethanol-sensitive Long-Sleep (LS) mice; in the ethanol-insensitive Short-Sleep (SS) mice which show marked activation to all subhypnotic doses of ethanol, these doses of apomorphine only attenuated the activation. A higher apomorphine dose (8 microM/kg) antagonized the locomotor depressant effects of 2.0 and 2.5 g/kg of ethanol in LS mice but did not alter the shape of the SS ethanol dose response curve for locomotor activity. Apomorphine (2 and 8 microM/kg) potentiated ethanol-induced loss of the righting reflex in LS mice in a dose dependent fashion, but did not alter this soporific effect of ethanol in SS mice. These findings extend the data base suggesting a role for dopamine both in the mechanism(s) differentiating the LS and SS mice and the stimu...Continue Reading

References

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Citations

Jan 1, 1989·Psychopharmacology·B C Dudek, T J Phillips
Sep 15, 1989·Experientia·T J PhillipsJ C Crabbe
May 1, 1986·Pharmacology, Biochemistry, and Behavior·J MasurA P Zwicker
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·A P Ferko, E Bobyock
Aug 1, 1993·Pharmacology, Biochemistry, and Behavior·W CaoA C Collins
Jan 1, 1984·Progress in Neurobiology·J J Feigenbaum, J Yanai
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·M MiquelC M Aragòn
Mar 1, 1991·Alcoholism, Clinical and Experimental Research·B C DudekM E Hahn
Nov 5, 1997·Alcoholism, Clinical and Experimental Research·D DavidsonR Swift
Apr 26, 2006·Alcoholism, Clinical and Experimental Research·Jean-Marc AssaadRichard E Tremblay
May 1, 1984·Alcoholism, Clinical and Experimental Research·B C Dudek, M E Abbott

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