PMID: 6410288Jun 1, 1983Paper

Apomorphine-induced biphasic circling behaviour in 6-hydroxydopamine-lesioned rats. A pharmacological kindling phenomenon

Naunyn-Schmiedeberg's Archives of Pharmacology
D M Coward

Abstract

Factors governing the development of apomorphine-induced biphasic circling behaviour in rats having unilateral 6-hydroxydopamine lesions of the substantia nigra were investigated. It was found that a post-lesion time of at least 2--3 weeks and the repeated exposure to apomorphine were essential for its development. Optimal results were obtained when animals received weekly apomorphine, 0.05 mg/kg sc, in post-lesion weeks 6, 7 and 8. Pretreatment with haloperidol, 1.0 and 2.0 mg/kg ip 1 h beforehand in post-lesion week 9, converted the biphasic response into an enhanced, uniphasic one. The findings suggest that the development of the biphasic response to apomorphine is a multi-factorial process representing a pharmacological kindling phenomenon.

References

Jan 1, 1966·Acta Pharmacologica Et Toxicologica·N E AndénK Larsson
Mar 1, 1969·International Journal of Neuropharmacology·G Stille, A Sayers
Mar 7, 1980·European Journal of Pharmacology·C OberlanderJ R Boissier

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Citations

Apr 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·U BonuccelliA Muratorio
Jan 1, 1987·Neurochemistry International·P Seeman, D Grigoriadis
Jun 7, 1986·Journal of Theoretical Biology·F Alonso-deFloridaM A Morales

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