PMID: 6404503Mar 7, 1983Paper

Apomorphine-induced changes in local cerebral blood flow in normal rats and after lesions of the dopaminergic nigrostriatal bundle

Brain Research
M IngvarU Stenevi

Abstract

Systemic administration of the dopamine (DA) receptor agonist apomorphine leads to a general increase in cerebral blood flow (CBF) as determined by the autoradiographic iodoantipyrine technique. The magnitude of the increase varies between different regions but shows no obvious relation to the density of either DA terminals or receptors. The circulatory response is much more prominent in the lateral than in the medial caudate-putamen. Apomorphine seems to increase CBF both via a change in metabolic rate and via stimulation of dilatory vascular receptors. In animals with unilateral 6-hydroxydopamine lesions of the ascending DA pathways apomorphine induces an augmented CBF response in some denervated structures, notably caudate-putamen and globus pallidus. It is concluded that this is partly due to stimulation of denervated supersensitive vascular receptors, suggesting a direct dopaminergic control of the blood vessels in these areas.

References

Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·G C CotziasJ Z Ginos
Sep 1, 1967·The Journal of Pharmacy and Pharmacology·N E AndénT Hökfelt
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B K HartmanS Udenfriend
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N DahlgrenB K Siesjö

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Citations

Nov 19, 1986·European Journal of Pharmacology·G BianchiS Garattini
Jan 1, 1993·Brain Research Bulletin·P A KelleyI M Ritchie
Aug 1, 1991·British Journal of Clinical Pharmacology·U SabatiniJ L Montastruc
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shigeki HiranoDavid Eidelberg
Jun 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D C ChuganiM E Phelps
Jul 19, 2000·Journal of Neurophysiology·K J BlackJ S Perlmutter

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