Apoptin induces apoptosis in an oral cancer mouse model

Cancer Biology & Therapy
Remilio A L SchoopM H Noteborn

Abstract

Apoptin, a chicken anemia virus-derived protein, induces apoptosis in various tumor cell lines and xenografted tumors. Its apoptotic activity is not hampered by tumor-suppressor p53 mutations or overexpression of anti-apoptosis proteins Bcl-2 or Bcl-x(L). We report for the first time the effects of apoptin expression in primary oral tumors, induced by the carcinogen 4-Nitroquinoline- 1-oxide in immunocompetent mice. In vivo a significant amount of primary oral tumor cells expressing apoptin cells underwent apoptosis, whereas synthesis of the LacZ control product did not. Ectopical expression of apoptin in passage 1 cell cultures derived from these oral tumors also resulted in apoptin-induced. Both in-vivo and in-vitro treated cells underwent apoptosis via the activation of caspase-3. The fact that apoptin induces apoptosis in primary squamous cell carcinoma cells indicates that apoptin is a potential therapeutic agent for treatment of head and neck squamous cell carcinoma.

Citations

Aug 18, 2009·Journal of Molecular Histology·Remilio A L SchoopRobert J Baatenburg de Jong
Jul 3, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qianqian LiTingxiu Xiang
Aug 29, 2014·Trends in Molecular Medicine·Oscar M Rollano PeñalozaMarek J Łos
Oct 31, 2009·Basic & Clinical Pharmacology & Toxicology·Remilio A L SchoopMathieu H M Noteborn
Sep 13, 2012·Biochimie·Olga A KovalVladimir A Richter
Apr 21, 2009·Biochimica Et Biophysica Acta·Marek LosKlaus Schulze-Osthoff
Nov 20, 2014·Cellular and Molecular Life Sciences : CMLS·Shishir Kumar GuptaA K Tiwari
Jul 31, 2012·International Journal of Molecular Medicine·Lei LiuBaorong Chi
Apr 17, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Hui ZhanMing-Xia Ding
Apr 30, 2009·Cancer Prevention Research·Lynn Vitale-CrossJ Silvio Gutkind

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