Apoptosis, airway inflammation and anti-asthma therapy: from immunobiology to clinical application

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Fabrizio SpinozziF M de Benedictis

Abstract

T lymphocyte apoptosis is essential for maintaining immune system homeostasis. Experimental evidence suggests apoptosis control mechanisms may be impaired in inflammatory conditions, particularly airway Th2-type allergic diseases. This review briefly examines the mucosal immune system homeostasis and common apoptotic pathways and discusses impaired apoptosis, allergy, airway inflammation, remodelling and fibrosis. Finally, the paper presents an update on pharmacological targeting of apoptosis to control airway inflammation in patients with allergic asthma.

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Citations

Jun 15, 2010·Respiratory Research·Carl G Persson, Lena Uller
Aug 27, 2011·Respiratory Research·Berislav BosnjakMichelle M Epstein
Sep 17, 2013·Cellular & Molecular Immunology·Jasmeet Kaur ChhabraBhola Nath Paul
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Jun 9, 2012·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Wei KouSu-Ling Hong
Oct 31, 2019·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Juan WangBei He
Mar 5, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Michał K ZarobkiewiczAgnieszka Bojarska-Junak

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