PMID: 9435462Jan 22, 1998Paper

Apoptosis and cell culture technology

Advances in Biochemical Engineering/biotechnology
M al-Rubeai

Abstract

The importance of apoptosis in cell culture has now been widely recognised. Recent work has shown that this process is widely manifested during the in vitro cultivation of commercially important mammalian cell lines. In this review I summarise what is now known of the characteristics, significance and regulatory mechanisms of apoptosis. As the process of cell proliferation and cell death are now considered intimately related, particular attention is paid to highlight the progress and opportunities in the field of cell culture engineering. The strategies that have been undertaken to prevent the induction of apoptosis in cell culture and those which have been suggested as possibilities to improve culture productivity through the apoptosis route are discussed with given examples.

Citations

Jun 30, 2005·Biotechnology and Bioengineering·Gisela G Chiang, William P Sisk
Nov 13, 2008·Cytotechnology·Darrin KuystermansMohamed Al-Rubeai
Oct 29, 2005·Biotechnology and Bioengineering·Carlota Diaz Sanchez-BustamanteMartin Fussenegger
Nov 13, 2008·Cytotechnology·Rodrigo C V PintoLeda R Castilho
May 20, 1998·Current Opinion in Biotechnology·M al-Rubeai, R P Singh

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