PMID: 9550311Apr 29, 1998Paper

Apoptosis and cellular proliferation in human epidermal squamous cell neoplasia

Journal of Cutaneous Pathology
T MakinoH Ito

Abstract

We examined cell loss (apoptosis) and proliferation in a histopathological spectrum of epidermal squamous cell neoplasia, including 11 cases of solar keratosis (SK), 18 Bowen's diseases (BD) and 19 invasive squamous cell carcinomas (SCC). Apoptotic and proliferative cells were determined by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-digoxigenin nick end labeling (TUNEL) and by the detection of nuclear antigen Ki-67, respectively. Few apoptotic cells were observed in normal epidermis, while TUNEL index (TI; percentage of TUNEL-positive cells) was highest for SCCs, followed by BDs and SKs, in the order given. Although the mean Ki-67 index did not differ between SCCs and BDs, both disease types showed a significantly higher index than the SKs. Of SCCs, both TI and Ki-67 index values were significantly higher in poorly than in well differentiated carcinomas. TI was significantly higher in SCCs without P53 immunohistochemical expression than in SCCs with P53 expression, while TI and Ki-67 indices did not correlate with P53 expression in the SKs and BDs. These results suggest that apoptosis reflects not only cell loss, but also proliferative activity in the epidermal neoplastic lesions.

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Citations

Sep 5, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·A Lakshmi KesariM Radhakrishna Pillai
Jul 24, 2003·The American Journal of Dermatopathology·Meora FeinmesserElimelech Okon
Nov 2, 2007·The Journal of Dermatology·Hidemichi KuboTakuro Kanekura
Jun 20, 2006·Pathology, Research and Practice·Tanja BatinacGordana Zauhar
Feb 14, 2004·The Australasian Journal of Dermatology·John P Arlette, Martin J Trotter
Apr 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tetsuo ShukuwaTakehiko Koji
Sep 15, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·R DoiH Ito

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