Apoptosis and differential expression of apoptosis-related proteins in endometriotic glandular and stromal cells

Journal of the Society for Gynecologic Investigation
Anastasia G GoumenouAydin Arici

Abstract

Apoptosis is an important regulator of eutopic endometrial function. Endometriosis, the growth of endometrial tissue outside the uterus, could result from increased cellular proliferation or decreased apoptosis in response to appropriate stimuli. The objective of this study was to evaluate the rate of apoptosis and the expression of apoptosis-related Bcl-2 and Bax proteins in endometriotic tissues within the glandular and stromal compartments, according to the phase of the menstrual cycle and the stage of disease. Ovarian endometriosis samples were evaluated in 75 women who had surgery at a university hospital. Apoptotic cells were detected with the use of the dUTP nick-end labeling (TUNEL) assay. Bcl-2 and Bax expression were assessed by immunohistochemical techniques. The percentage of apoptotic cells was significantly higher in endometriotic stromal cells (73.3%) compared with glandular cells (48%; P =.002). In contrast, the expression of the apoptosis-related proteins Bcl-2 and Bax was significantly lower in the endometriotic stroma (17.3% for both) than in the glandular epithelium (38.6% and 41.3%, respectively; P <.004). No significant menstrual cycle phase-dependent changes or endometriosis stage-related changes were obs...Continue Reading

References

Jul 1, 1976·The Journal of Pathology·D Hopwood, D A Levison
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
May 1, 1996·Molecular Human Reproduction·M HaradaK Furui
Aug 15, 2000·Molecular and Cellular Endocrinology·T E VaskivuoJ S Tapanainen
Feb 13, 2001·Fertility and Sterility·D I LebovicR N Taylor
Jul 31, 2001·Fertility and Sterility·W B Nothnick
Feb 28, 2002·Human Reproduction Update·Thomas M D'Hooghe, Sophie Debrock
Apr 13, 2002·Annals of the New York Academy of Sciences·Aydin Arici
Apr 13, 2002·Annals of the New York Academy of Sciences·Robert M BrennerRodney W Kelly
Aug 21, 2002·Gynecologic and Obstetric Investigation·Helena J M M MertensJohannes L H Evers
Sep 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Onder BozdoğanMerih Bayram
Nov 1, 1953·American Journal of Obstetrics and Gynecology·R B SCOTTL R WHARTON
Oct 1, 1961·American Journal of Obstetrics and Gynecology·J H RIDLEY
Feb 1, 1951·American Journal of Obstetrics and Gynecology·W C KEETTEL, R J STEIN

❮ Previous
Next ❯

Citations

Mar 30, 2013·Human Reproduction Update·Fernando M ReisRobert N Taylor
Nov 23, 2007·Gynecologic and Obstetric Investigation·Joanna Skret-MagierloAndrzej Skret
Aug 16, 2006·Reproductive Biology and Endocrinology : RB&E·Lukasz WicherekBeata Kleinrok-Podsiadlo
Oct 17, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·D KorkmazF Buyru
Dec 25, 2009·Reproductive Biomedicine Online·Ozgur CinarAydin Arici
Jul 28, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ae Ra HanHwa Young Lee
Mar 22, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Simin Mirakhor SamaniDaniel F Fouladi
Mar 1, 2007·Neurosurgery·Ronald E BattCharles Chapron

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis