Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes

Arthritis and Rheumatism
T NakajimaK Nishioka

Abstract

To determine whether apoptosis occurs in rheumatoid arthritis (RA) synoviocytes, and if this phenomenon is dependent on the Fas/Apo-1 pathway. Apoptotic change in vivo was examined in RA synovial cells by several standard methods. The ability of cells to undergo Fas-induced apoptosis was determined in vitro. Typical apoptotic change was demonstrated in RA synovial cells by each method. Anti-Fas antibody induced apoptotic synovial cell death in vitro. This is the first reported study to demonstrate apoptosis in RA synovial cells. The findings indicate that rheumatoid synoviocytes undergo Fas-mediated apoptosis.

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Citations

Jan 20, 1998·Arthritis and Rheumatism·K NishiokaT Kobata
Nov 11, 1999·Arthritis and Rheumatism·A KawakamiK Eguchi
Aug 1, 1996·Arthritis and Rheumatism·K NishiokaT Hasunuma
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Jun 12, 2013·Rheumatology International·Seyfi YıldırMehmet Emin Erdal
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Mar 5, 1998·Clinical and Experimental Immunology·T RèmeJ Sany
Nov 13, 2001·Clinical and Experimental Immunology·K MigitaK Eguchi

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis