Apoptosis and its correlation with proliferative activity in rectal cancer

Journal of Surgical Oncology
Young-Ho KimKyoo Wan Choi

Abstract

Alterations in the normal control of apoptosis and cell proliferation are important factors in multistep colorectal carcinogenesis. The aim of this study was to determine the frequency of apoptosis and cell proliferation in rectal cancers and to examine their relationship to clinicopathological variables and expression of bcl-2 and p53. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) staining and immunohistochemical staining for Ki-67, bcl-2, and p53 were performed on paraffin-embedded tissue samples of 57 rectal cancers. There was a positive linear correlation between apoptotic index (AI) and proliferative index (PI) (gamma = 0.276, P = 0.038). Both apoptosis and cell proliferation were more frequently found in rectal cancers with lymph node metastasis (P = 0.045 and 0.010, respectively). However, the ratio of AI and PI was not different by nodal status. There was no association between Dukes stage and AI or PI. The frequency of apoptosis was inversely related to the expression of bcl-2, but was not related to the p53 status of rectal cancer. There were no association between cell proliferation and the expression of bcl-2 or p53. Our results suggest that the susceptibility to apoptosis in re...Continue Reading

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Citations

Mar 5, 2003·Medical Hypotheses·Mark A Brudnak, Stephanie G Hoener
Oct 11, 2013·BMC Clinical Pathology·Julia AlcaideMaximino Redondo
Jun 3, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Inti ZlobecJeremy R Jass
Apr 9, 2019·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maximino RedondoUNKNOWN REDISSEC-CARESS/CCR group
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Mar 22, 2014·Molecular and Clinical Oncology·Yoshitake UedaSeigo Kitano
Aug 25, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stig Linder

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