Apoptosis and necrosis: a review for surgeons

Surgical Infections
Patrick McHugh, Matthias Turina

Abstract

Orderly cell death, termed apoptosis, features a morphology that is distinct from necrotic, or accidental, cell death. As the body of literature on apoptotic cell death grows, it is difficult for practicing surgeons to stay current with the involved mechanisms and their biologic significance. A MEDLINE/PubMed literature search was conducted, followed by manual crossreferencing, to identify relevant articles published in the English language between 1972 and 2004. Apoptosis is now known to be involved in numerous disease states. Ischemia-reperfusion injury and acute pancreatitis are but two surgical entities in which the balance of apoptotic and necrotic cell death has a profound effect on clinical outcome. Similarly, the timing and extent of apoptosis in immune cells are important factors that determine the outcome of septic patients. As already demonstrated in animal models, further research in this field will target opportunities for therapeutic intervention, making it increasingly important for clinicians to be familiar with apoptosis and necrosis, and their roles in normal and pathologic states.

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Citations

Oct 12, 2012·Apoptosis : an International Journal on Programmed Cell Death·Gang WangBei Sun
Apr 25, 2006·Surgical Infections·Matthias TurinaHiram C Polk
May 31, 2014·Toxicon : Official Journal of the International Society on Toxinology·Clarissa P MelloAlice M C Martins
Dec 20, 2007·The Journal of Trauma·Matthias TurinaWilliam G Cheadle
Aug 10, 2006·American Journal of Physiology. Renal Physiology·Jun Xie, Qing Guo
May 2, 2014·Case Reports in Infectious Diseases·Milana Obradovic-TomasevMladen Jovanovic
Dec 16, 2020·Protein and Peptide Letters·Meishan ChenQiuxiang Pang

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Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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