Apoptosis and non-apoptotic deaths in cancer development and treatment response

Cancer Treatment Reviews
Elza C de Bruin, Jan Paul Medema

Abstract

Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to expand even in a stressful environment. Cells resistant to apoptosis are also assumed to be resistant to anti-cancer therapies. Apoptosis has therefore taken a central position in cell death research. However, its contribution to treatment success is highly debated for solid tumors. It becomes more and more clear that cells can also die by non-apoptotic mechanisms, such as autophagy, mitotic catastrophe and necrosis. In this review, we summarize the current knowledge regarding the molecular pathways that underlie these apoptotic and non-apoptotic death pathways, and discuss the clinical data that have now accumulated to evaluate their roles in tumor development and cancer treatment.

References

May 1, 1994·International Journal of Cancer. Journal International Du Cancer·P MöllerP H Krammer
Nov 1, 1993·Nature Genetics·M HarveyL A Donehower
Feb 7, 1997·Cell·S Nagata
Jul 10, 1997·Nature·M IrmlerJ Tschopp
Aug 1, 1997·Nature Medicine·G AmbrosiniD C Altieri
Apr 1, 1998·Nature·D P CahillB Vogelstein
Jun 6, 1998·The Journal of Experimental Medicine·D VercammenP Vandenabeele
Jun 20, 1998·The Journal of Cell Biology·P JinD O Morgan
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·A TannapfelC Wittekind
Sep 9, 1998·The Journal of Experimental Medicine·D VercammenP Vandenabeele
Oct 6, 1998·Nature·N MizushimaY Ohsumi
Feb 18, 1999·Current Opinion in Chemical Biology·E C JonathanW G McKenna
Mar 20, 1999·The Journal of Biological Chemistry·H R StennickeG S Salvesen
Oct 6, 1999·The Journal of Experimental Medicine·J P MedemaR Offringa
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·H C Ha, S H Snyder
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jun 30, 2000·The New England Journal of Medicine·G SteinbachG Kelloff
Aug 10, 2000·Nature Structural Biology·M A VerdeciaJ P Noel
Sep 6, 2000·Nature Medicine·C A SchmittS W Lowe
Sep 12, 2000·Nature Cell Biology·V A SmitsR H Medema
Dec 2, 2000·Science·D J Klionsky, S D Emr
Mar 27, 2001·The Journal of Cell Biology·N MizushimaT Yoshimori

❮ Previous
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Citations

Jul 20, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zuzana ZacharPaul M Bingham
Jul 28, 2009·Apoptosis : an International Journal on Programmed Cell Death·Angeliki KoryllouVassiliki Pletsa
Oct 24, 2009·Apoptosis : an International Journal on Programmed Cell Death·Sowmyalakshmi SrinivasanChendil Damodaran
Nov 26, 2010·Apoptosis : an International Journal on Programmed Cell Death·Miaoxin LinZijian Guo
Jan 10, 2012·Apoptosis : an International Journal on Programmed Cell Death·Kristel KemperJan Paul Medema
Oct 19, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Pierre ChampelovierAhcène Boumendjel
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Sasipawan MachanaSahapat Barusrux
Nov 26, 2011·Cell Death and Differentiation·M BartucciR De Maria
Feb 9, 2013·Cell Death & Disease·H L LanzC Backendorf
Nov 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ferdia A GallagherKevin M Brindle
Sep 26, 2009·Antioxidants & Redox Signaling·Matteo LandriscinaFranca Esposito
Aug 22, 2009·Cancer Biotherapy & Radiopharmaceuticals·Christel VangestelMarc Peeters
Jan 6, 2011·Cancer Biotherapy & Radiopharmaceuticals·Janice KaptyJohn Mercer
Dec 24, 2009·Carcinogenesis·Armando RojasErik Morales
Sep 14, 2011·Journal of Innate Immunity·Geetha Srikrishna
Jan 9, 2013·Journal of Translational Medicine·Julien LaurentDaniel E Speiser
Oct 16, 2009·Annals of Surgical Oncology·Takeshi NishikawaHirokazu Nagawa
Oct 17, 2012·International Journal of Nanomedicine·Tsung-Lin TsaiWu-Chou Su
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Lada Rumora, Tihana Zanić Grubisić
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·R Adam SmithH Charles Manning
Dec 29, 2013·Apoptosis : an International Journal on Programmed Cell Death·Yu-Fan WangZhi-Jun Sun
Apr 1, 2014·Cell Death and Differentiation·S ColakJ P Medema
Jul 2, 2014·BMC Complementary and Alternative Medicine·Amirah Abdul RahmanWan Zurinah Wan Ngah
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Yongqiang ChenSpencer B Gibson
Jul 24, 2013·Expert Review of Anticancer Therapy·Xinfang YuYa Cao
Feb 11, 2016·BMC Complementary and Alternative Medicine·Chao ZhangChengwei He
Nov 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Makako YamanakaMasatoshi Tagawa
Jan 24, 2016·Pharmacology & Therapeutics·Dongjoo LeeKyeong Sook Choi
Feb 3, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Tatiana V DenisenkoBoris Zhivotovsky
Jul 31, 2012·The Journal of Nutritional Biochemistry·Cristina P R XavierCristina Pereira-Wilson
May 15, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Karlien le RouxNamrita Lall
Feb 25, 2011·Cancer Letters·Verena Jendrossek
Nov 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Ervinna PangJ Guy Lyons

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