Apoptosis and phosphatidylserine-mediated recognition during the take-over phase of the colonial life-cycle in the ascidian Botryllus schlosseri

Cell and Tissue Research
Francesca CimaLoriano Ballarin

Abstract

Colonies of the ascidian Botryllus schlosseri undergo recurrent generation changes in which adult zooids are gradually resorbed and replaced by new blastogenic generations. During these periods, known as take-over phases, programmed cell death, which, on the basis of morphological analysis is ascribed to apoptosis, occurs widely in zooid tissues. In the present report, we re-investigate cell death during the take-over process. Results confirm the occurrence of diffuse apoptosis, as evidenced by chromatin condensation, positivity to the TUNEL reaction and expression of phosphatidylserine on the outer leaflet of the plasma membrane. Apoptosis also occurs among haemocytes, and senescent blood cells are actively recognised and ingested by circulating professional phagocytes. Both phosphatidylserine and CD36, a component of the thrombospondin receptor, are involved in the recognition of apoptotic haemocytes, which fosters the idea that fundamental recognition mechanisms are well conserved throughout chordate evolution.

Citations

Mar 5, 2009·In Vitro Cellular & Developmental Biology. Animal·Claudette RabinowitzBaruch Rinkevich
Nov 30, 2010·Immunobiology·Nicola FranchiLoriano Ballarin
May 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Raffaella Tarallo, Paolo Sordino
Jan 30, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Fabio GaspariniGiovanna Zaniolo
Dec 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L ManniL Ballarin
Mar 7, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Amalia RosnerBaruch Rinkevich
Dec 25, 2012·Journal of Invertebrate Pathology·Nicola FranchiLoriano Ballarin
Feb 24, 2007·Developmental Biology·Amalia RosnerBaruch Rinkevich
May 2, 2009·Developmental Biology·Amalia RosnerBaruch Rinkevich
Apr 24, 2016·Developmental and Comparative Immunology·Nicola FranchiLoriano Ballarin
Jun 27, 2017·Frontiers in Immunology·Nicola Franchi, Loriano Ballarin
Feb 15, 2019·Developmental Biology·Delany RodriguezAnthony W De Tomaso
Mar 24, 2004·The Journal of Experimental Biology·Claudette Rabinowitz, Baruch Rinkevich

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis