PMID: 8971027Dec 1, 1996Paper

Apoptosis and T-cell depletion during feline infectious peritonitis

Journal of Virology
B L HaagmansM C Horzinek

Abstract

Cats that have succumbed to feline infectious peritonitis, an immune-mediated disease caused by variants of feline coronaviruses, show apoptosis and T-cell depletion in their lymphoid organs. The ascitic fluid that develops in the course of the condition causes apoptosis in vitro but only in activated T cells. Since feline infectious peritonitis virus does not infect T cells, and viral proteins did not inhibit T-cell proliferation, we postulate that soluble mediators released during the infection cause apoptosis and T-cell depletion.

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Citations

Dec 3, 2005·Nature Reviews. Immunology·Stanley Perlman, Ajai A Dandekar
May 5, 2010·Journal of the American Animal Hospital Association·Kristin M Lewis, Robert T O'Brien
Jul 9, 2020·Canadian Journal of Microbiology·Marvin Paulo Lins, Salete Smaniotto
Jun 2, 2009·Journal of Feline Medicine and Surgery·Diane AddieMarian C Horzinek
Jun 24, 2011·PloS One·Ana M MaestreDolores Rodríguez
Sep 21, 2015·Apoptosis : an International Journal on Programmed Cell Death·Ahmad Naqib ShuidAbdul Rahman Omar
Mar 10, 1999·The Veterinary Record·A KiparM Reinacher
Apr 25, 2007·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Lu ZhangRan Fei
Feb 27, 2014·Veterinary Pathology·A Kipar, M L Meli
Jun 2, 2004·Journal of Medical Virology·Huimin YanGeorge F Gao
Dec 23, 2004·Journal of Virology·Jolanda D F de Groot-MijnesRaoul J de Groot
Oct 30, 2004·Pediatric Pulmonology·A M LiT F Fok
Nov 19, 2003·Journal of Feline Medicine and Surgery·J E FoleyC Leutenegger
Dec 5, 1998·Veterinary Immunology and Immunopathology·T MizunoA Hasegawa

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis