PMID: 9178072Jan 1, 1997Paper

Apoptosis and the B cell response to antigen

International Reviews of Immunology
D M Tarlinton, K G Smith

Abstract

The primary B cell response to T cell dependent antigens comprises two pathways of differentiation; one resulting in formation of foci of antibody forming cells in the extrafollicular regions of secondary lymphoid organs and the other giving rise to germinal centers within the follicles. Foci of antibody forming cells are detectable for only a limited time, before involuting due to apoptosis of the plasma cells. Similarly in the germinal center, regulation of cell number, selection of high affinity variants generated by somatic hypermutation, and the resolution of the germinal center itself all involve the death of unwanted B cells. In this review we describe recent experiments which have allowed determination of the role of certain forms of apoptosis in the B cell response to antigen.

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Citations

May 5, 2001·Pharmacology & Therapeutics·K SharmaY F Shi
Jan 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiko KuwaharaNobuo Sakaguchi
Oct 19, 2007·Seminars in Immunopathology·Menna R Clatworthy, Kenneth G C Smith
Jan 29, 2008·Seminars in Immunology·Kirsten A FairfaxDavid M Tarlinton
Aug 15, 2000·Annual Review of Nutrition·W H WatsonD P Jones
Sep 16, 2006·Nature Reviews. Immunology·Andreas RadbruchFalk Hiepe
Mar 26, 2021·Journal of Virology·D Scott SchmidMyron J Levin

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