PMID: 9552392Jan 1, 1996Paper

Apoptosis and the cell cycle

Progress in Cell Cycle Research
R FotedarA Fotedar

Abstract

Apoptosis is a genetically controlled response by which eukaryotic cells undergo programmed cell death. This phenomenon plays a major role in developmental pathways (1), provides a homeostatic balance of cell populations, and is deregulated in many diseases including cancer. Control of cell number is determined by an intricate balance of cell death and cell proliferation. Accumulation of cells through suppression of death can contribute to cancer and to persistent viral infections, while excessive death can result in impaired development and in degenerative diseases. Identification of genes that control cell death, and understanding of the impact of apoptosis in both development and disease has advanced our knowledge of apoptosis in the past few years. There appears to be a linkage between apoptosis and cell cycle control mechanisms. Elucidating the mechanisms that link cell cycle control with apoptosis will be of key importance in understanding tumour progression and designing new models of effective tumour therapy.

Citations

Sep 24, 2010·Journal of Virology·Yuan HeBing Sun
May 23, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yuko ItoYoshinori Otsuki
Oct 19, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Edward Parr
Sep 30, 2014·International Journal of Food Sciences and Nutrition·Qisen XiangRuiling Shen
Mar 16, 2004·The European Journal of Neuroscience·Juha-Pekka KalkkilaJari Honkaniemi
Apr 10, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·I Salles-PassadorR Fotedar
Jan 5, 2005·Journal of Comparative Pathology·Y HosakaK Takehana
May 15, 2007·Molecular Aspects of Medicine·Jiri NeuzilStephen J Ralph
Aug 4, 2005·BMC Biology·Carrie Dickey-SimsJames A Coffman

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