PMID: 8946072Jul 1, 1996Paper

Apoptosis and vascular wall remodeling in hypertension

Canadian Journal of Physiology and Pharmacology
P HametJ Tremblay

Abstract

Vascular structure plays a key role in the pathogenesis of hypertension. Because it is less readily reversible than protein accumulation, DNA accumulation in the arterial wall may be considered as a record of past episodes of vascular growth, contributing to the persistence of the vascular disease. Apoptosis, a ubiquitous and highly regulated form of programmed cell death that is involved in tissue morphogenesis and homeostasis as the essential counterpart of cell replication, is potentially involved in the regulation of vascular structure, via the deletion of cells in the vessel wall. We discuss how the current knowledge on apoptosis may provide insights into the pathogenesis of vascular wall remodeling, with an emphasis on the biology of vascular smooth muscle cells. Evidence suggests that heightened cell replication rates are often associated with increased apoptosis, as for smooth muscle cells in genetic hypertension or in arterial repair after injury. However, apoptotic cell death may also be regulated independently of cell growth. The triggering of apoptosis depends on a balance of environmental cues that are not specific to apoptosis. However, there is a common set of key biochemical events mediating apoptosis (i.e., com...Continue Reading

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Citations

Jun 19, 2001·Experimental Gerontology·M Mayr, Q Xu
Jan 1, 1998·Trends in Cardiovascular Medicine·A Karsan
Oct 24, 1998·The International Journal of Biochemistry & Cell Biology·A López-FarréS Casado
Nov 16, 2007·Kidney & Blood Pressure Research·Zhangping Peng, William J Arendshorst
Mar 7, 2008·Antioxidants & Redox Signaling·Moo Yeol Lee, Kathy K Griendling
May 4, 2011·World Journal of Biological Chemistry·Zhiguo Wang
Mar 10, 2001·Journal of Vascular Surgery·C XuC K Zarins
Aug 24, 2007·The Journal of Surgical Research·Francesco OnoratiAttilio Renzulli
Feb 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhi-Qiang QianDan-Li Yang
Sep 1, 1996·Hypertension·P Hamet
Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·I M BayerB L Langille
May 4, 2002·Circulation Research·Zane S JacksonB Lowell Langille
Jul 29, 2000·Canadian Journal of Physiology and Pharmacology·E S Werstiuk, R M Lee
Mar 25, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Rheure Alves Moreira LopesRita C Tostes

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