PMID: 9525002Apr 3, 1998Paper

Apoptosis as a prognostic factor in colorectal carcinoma

Surgery Today
K SugamuraN Kaibara

Abstract

We investigated the occurrence of apoptotic cell death in 104 colorectal carcinomas by terminal-deoxynucleotidyl-transferase-mediated dUTP-diotin nick end-labeling (TUNEL) to determine whether apoptosis could be a useful prognostic factor. The apoptotic index (AI) was calculated as the percentage of positive cancer cells per 1,000 cancer cells, the median AI being 4.1, with a range of 1.9-4.7. Apoptosis was less frequently observed in tumors with higher malignant potential, such as those at advanced stages Dukes B, C and D, than those at Dukes stage A (P < 0.05); in tumors showing evidence of moderate differentiation than in well-differentiated tumors (P < 0.05); and in tumors with venous invasion or lymph node metastasis than in those without these features (P < 0.05). Moreover, the subgroup of patients with a low AI of < 4.1 had a significantly poorer survival rate than the subgroup with a high AI in tumors at Dukes stage C, the 5-year survival rates being 33% vs 68% (P < 0.05; Cox-Mantel). Our findings suggest that less apoptosis might result in a greater progression of colorectal carcinoma, and that the rate of apoptosis might be an indicator of the degree of malignancy. Thus it would appear that the frequency of apoptosis ...Continue Reading

Citations

Mar 29, 2002·Journal of Surgical Oncology·Young-Ho KimKyoo Wan Choi
Jan 10, 2006·Diseases of the Colon and Rectum·Marja HilskaPeter J Roberts
Dec 17, 2002·Critical Reviews in Oncology/hematology·J J KoornstraJ H Kleibeuker
May 4, 2006·Inflammatory Bowel Diseases·Karen L EdelblumD Brent Polk
Dec 2, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A FariedH Kuwano
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joanne R Brown, Raymond N DuBois
Dec 18, 2001·British Journal of Cancer·A RaoufJ V Reynolds
Mar 1, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Nenad KunacKatarina Vilović
Jun 21, 2003·Clinical Chemistry·Kevin A BoyntonAnthony P Shuber
May 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·L E JongesP J Kuppen
Aug 25, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stig Linder

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