PMID: 9171511Dec 1, 1996Paper

Apoptosis-associated proteins in oral hairy leukoplakia

Oral Diseases
E ChrysomaliJ A Regezi

Abstract

To test the hypothesis that the anti-apoptotic ability of Epstein-Barr virus (EBV) may result in altered expression of apoptosis-associated proteins in oral hairy leukoplakia (HL), we evaluated HL tissue and normal epithelium for these proteins by immunohistochemistry. Twenty formalin-fixed, paraffin-embedded specimens of HL lesions and six specimens of normal control mucosa were selected from archived tissue specimens. Bcl-2, Bcl-x, Bax and p53 apoptosis-associated proteins were evaluated in immunohistochemically stained tissue sections according to staining intensity and pattern. The percentage of p53-positive basal cells was estimated in sequential fields. Generally, there were only slight differences in the expression of Bcl-2 and Bcl-x proteins in the epithelium of HL and control tissue. The staining for Bcl-2 was weaker in keratinocytes than in putative melanocytes and Langerhans cells. Equivocal diffuse cytoplasmic staining of prickle cells was also noted. Keratinocytes throughout the epithelium stained positively for Bcl-x protein, although upper layers were more weakly stained. The 'balloon' keratinocytes in HL were infrequently positive for Bcl-x. Bax staining in HL differed from that in control tissue in being more h...Continue Reading

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M HockenberyS J Korsmeyer
Feb 1, 1989·The American Journal of Surgical Pathology·C B FowlerR B Brannon
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W SedlakS J Korsmeyer
Sep 1, 1995·The Journal of Experimental Medicine·D T ChaoS J Korsmeyer
Sep 15, 1994·Cancer·K NakagawaM Ichihashi
Feb 1, 1994·Leukemia & Lymphoma·J FinkeG Dölken
Jan 1, 1994·The Journal of Cell Biology·J C Reed

❮ Previous
Next ❯

Citations

Jul 9, 1998·Oral Diseases·A T CruchleyJ S Greenspan
Mar 6, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Christophe DeschaumesJean C Ameisen
Aug 20, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mingbin ZhangWantao Chen
Feb 4, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Juan Carlos de VicenteManuel Florentino Fresno
Apr 16, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Koroku KatoEtsuhide Yamamoto
Apr 17, 2004·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Nikolaos G NikitakisStavros I Papanicolaou

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis