PMID: 8971021Dec 1, 1996Paper

Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome

Journal of Virology
J UsamiY Yoshikai

Abstract

CD95 (Fas)/CD95 ligand (CD95 L)-mediated apoptosis is thought to be involved in the delayed progression of murine AIDS (MAIDS) induced by LP-BM5 murine leukemia virus (MuLV). We show evidence of apoptosis in lymphocytes of Peyer's patches (PP) at the early stage of MAIDS. Both T and B cells in PP expressed CD95 at the early stage of MAIDS and decreased in number thereafter. The decrease in T cells was not evident in CD95-mutated lpr mice with MAIDS, suggesting that CD95/CD95 L interaction is involved in the apoptosis of T cells in PP during the course of MAIDS. On the other hand, the number of B cells was also decreased in PP of lpr mice with MAIDS. The proliferative ability of B cells in PP of MAIDS mice in response to immunoglobulin M cross-linking or lipopolysaccharide was severely impaired, while the B cells normally proliferated in response to anti-CD40 monoclonal antibody. These findings imply that aberrantly activated B cells in PP undergo apoptosis independently of the CD95/CD95 L system during the course of infection with MAIDS virus.

References

Oct 1, 1991·The Journal of Infectious Diseases·H DarbanR R Watson
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N KobayashiS Yonehara
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S K ChattopadhyayJ W Hartley
Jun 1, 1987·The Journal of Experimental Medicine·D E MosierH C Morse
Jan 1, 1994·Annual Review of Immunology·J BanchereauS Saeland
Oct 1, 1994·European Journal of Immunology·K HiromatsuY Yoshikai
Sep 1, 1994·Immunology Today·F H DurieR J Noelle
Feb 2, 1995·Nature·J DheinP H Krammer
Mar 10, 1995·Science·S Nagata, P Golstein
Mar 10, 1995·Science·G ChengD Baltimore
Dec 1, 1994·Immunological Reviews·P H KrammerM O Westendorp
Nov 1, 1995·The Journal of Experimental Medicine·P GarroneJ Banchereau
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M AdachiS Nagata
Dec 1, 1994·Immunology Today·G NúñezM González-García
Jan 1, 1994·The Journal of Clinical Investigation·Y Levy, J C Brouet
Jan 1, 1996·The Journal of Experimental Medicine·S Hess, H Engelmann

❮ Previous
Next ❯

Citations

Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Masayuki UmemuraYasunobu Yoshikai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis