PMID: 11913451Mar 27, 2002Paper

Apoptosis, cell volume regulation and volume-regulatory chloride channels

Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Y Okada, Emi Maeno

Abstract

Apoptosis occurs in response to various stimuli under physiological and pathological circumstances. A major hallmark of the programmed cell death is normotonic shrinkage of cells. Induction of the apoptotic volume decrease (AVD) was found to precede cytochrome c release, caspase-3 activation and DNA laddering. A broad-spectrum caspase inhibitor blocked these biochemical apoptotic events but failed to block the AVD. The normotonic AVD induction was coupled to facilitation of the regulatory volume decrease (RVD), which is attained by parallel operation of Cl- and K+ channels, under hypotonic conditions. Both the AVD induction and RVD facilitation were prevented by application of a blocker of volume-regulatory Cl- or K+ channels. Furthermore, apoptotic cell death was rescued by channel blocker-induced prevention of AVD. Thus, it is concluded that the AVD is produced under normotonic conditions by a mechanism similar, though without preceding swelling, to RVD and represents an early prerequisite to apoptotic events leading to cell death. It was previously reported that hypertonic stress triggers apoptosis in cell types that lack the regulatory volume increase (RVI) mechanism. Taken together, it is suggested that 'disordered' or alt...Continue Reading

References

Apr 1, 1989·Physiological Reviews·E K Hoffmann, L O Simonsen
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Sep 1, 1996·The American Journal of Physiology·C D Bortner, J A Cidlowski
Apr 1, 1996·The American Journal of Physiology·R S BensonA J Watson
Dec 31, 1997·The Journal of Biological Chemistry·F M HughesJ A Cidlowski
Feb 7, 1998·Pflügers Archiv : European journal of physiology·P Doroshenko
Jan 24, 1998·The Journal of Biological Chemistry·C D BortnerJ A Cidlowski
May 16, 1998·The Journal of Cell Biology·A Lepple-WienhuesF Lang
May 8, 1998·Journal of Neurochemistry·L V ColomS H Appel
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·I SzabòF Lang
Jun 17, 1998·The Journal of Biological Chemistry·A P FeranchakJ G Fitz
Sep 3, 1998·The Journal of General Physiology·Y OkadaS Morishima
Jan 28, 1999·The Journal of Biological Chemistry·L WangL Lu
Apr 21, 1999·Current Opinion in Cell Biology·H Li, J Yuan
Dec 28, 1999·Annual Review of Cell and Developmental Biology·I BudihardjoX Wang
Apr 28, 2000·The Journal of Biological Chemistry·H H NietschS D Lidofsky
Jul 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·E MaenoY Okada
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P Yu, D W Choi
Dec 23, 2000·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·E K Hoffmann

❮ Previous
Next ❯

Citations

May 11, 2006·The Journal of Membrane Biology·Y OkadaN Takahashi
May 11, 2006·The Journal of Membrane Biology·R FrancoJ A Cidlowski
Apr 6, 2006·Pflügers Archiv : European journal of physiology·Stine Falsig Pedersen
Jul 6, 2007·Pflügers Archiv : European journal of physiology·Lubica MalekovaKarol Ondrias
Mar 8, 2006·Apoptosis : an International Journal on Programmed Cell Death·H-N ZhangY-Y Guan
Jul 13, 2007·Apoptosis : an International Journal on Programmed Cell Death·Gerhard KrumschnabelClaudia Manzl
Dec 17, 2008·Apoptosis : an International Journal on Programmed Cell Death·Gerhard Krumschnabel, Jason E Podrabsky
Oct 27, 2009·Apoptosis : an International Journal on Programmed Cell Death·Geneviève Dupéré-MinierJacques Bernier
Mar 5, 2011·Apoptosis : an International Journal on Programmed Cell Death·Yan QianYong-Yuan Guan
Mar 31, 2012·Apoptosis : an International Journal on Programmed Cell Death·Katsuya DezakiYasunobu Okada
Apr 12, 2008·Purinergic Signalling·Ravshan Z Sabirov, Yasunobu Okada
Sep 10, 2003·Progress in Neurobiology·Shan Ping Yu
Oct 30, 2012·Acta Pharmacologica Sinica·Ya-ping ZhangDayue Darrel Duan
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takahiro ShimizuYasunobu Okada
Jun 1, 2006·Acta Physiologica·R Franchi-GazzolaO Bussolati
Oct 24, 2008·Acta Physiologica·I H LambertS F Pedersen
Sep 30, 2010·Acta Physiologica·E K Hoffmann, S F Pedersen
Jul 23, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Nobuyuki TakahashiYasunobu Okada
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hanne Sørup TastesenIan Henry Lambert
Jul 5, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jehad AlgharabilDandan Sun
Sep 11, 2010·Journal of Biomedical Science·Stephen W SchafferJunichi Azuma
Jan 17, 2008·Journal of Cell Science·Nola Jean ErnestHarald Sontheimer
Apr 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuo NittaMasahiro Hosono
Aug 27, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yasuo MoriYuji Imaizumi
Oct 3, 2013·PloS One·Hartmut M Hanauske-AbelMichael B Mathews
Jan 6, 2009·The International Journal of Developmental Biology·Marisabel Fernández-MongilLegier V Rojas
Nov 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stacey Watkins, Harald Sontheimer
Jul 7, 2007·Neurosurgical Focus·Danny LiangJ Marc Simard
Jan 25, 2012·International Journal of Molecular Sciences·Ranokhon S KurbannazarovaRavshan Z Sabirov
Sep 4, 2012·International Journal of Molecular Sciences·Yuichi HasegawaYasunobu Okada
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Carl D Bortner, John A Cidlowski
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Florian Lang, Christos Stournaras
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Else K Hoffmann, Ian H Lambert
Jun 27, 2015·International Journal of Molecular Sciences·Jennifer PasquierFrank Le Foll
Jan 27, 2010·FEBS Letters·Zuzana Tomaskova, Karol Ondrias
Jul 22, 2009·Biochemical and Biophysical Research Communications·Wanhong ZuoLiwei Wang
Sep 22, 2007·Analytical Biochemistry·Marcelo SaliernoRoberto Etchenique
Feb 17, 2007·Lancet Neurology·J Marc SimardVolodymyr Gerzanich
Apr 21, 2007·Progress in Retinal and Eye Research·Stefan Mergler, Uwe Pleyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis