Apoptosis distribution in the first molar tooth germ of the field vole (Microtus agrestis)

Tissue & Cell
E MatalovaI Misek

Abstract

Apoptosis represents an important process in organ and tissue morphogenesis and remodeling during embryonic development. A role for apoptosis in shape formation of developing teeth has been suggested. The field vole is a useful model for comparative studies in odontogenesis, particularly because of its contrasting molar morphogenesis when compared to the mouse. However, little is known concerning apoptosis in tooth development of this species. Morphological (cellular and nuclear alterations) and biochemical (specific DNA breaks--TUNEL staining) characteristics of apoptotic cells were used to evaluate the temporal and spatial occurrence of apoptosis in epithelial and mesenchymal tissues of the developing first molar tooth germs of the field vole. Apoptotic cells were found in non-proliferating areas (identified previously) throughout bud to bell stages, particularly in the epithelium, however, scattered also in the mesenchyme. A high concentration of TUNEL positive cells was evident in primary enamel knots at late bud stage with increasing density of apoptotic cells until ED 16 when the primary enamel knot in the field vole disappears and mesenchyme becomes protruded in the middle axes of the bell forming two shallow areas with ...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Aug 1, 1986·Journal of Dental Research·A R Ten Cate, R D Anderson
Jan 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M Shear
Oct 1, 1996·European Journal of Oral Sciences·L VermelinM Goldberg
May 1, 1997·Anatomy and Embryology·H KanekoM Shimono
Dec 10, 1997·Mechanisms of Development·I Thesleff, P Sharpe
Apr 16, 1998·European Journal of Oral Sciences·J C FranquinJ Dejou
May 18, 1999·Journal of Dental Research·A S Tucker, P T Sharpe
Jan 22, 2000·Developmental Biology·J PispaI Thesleff
Jun 17, 2000·Histochemistry and Cell Biology·A L BronckersS M van den Eijnde
Oct 26, 2000·Nature·P MeierG Evan
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·J JernvallI Thesleff
May 31, 2001·Nature Genetics·A M RangerS J Korsmeyer
Jun 13, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·G TsukamotoT Matsumura
Dec 20, 2002·Connective Tissue Research·R PeterkováH Lesot
Mar 5, 2003·Archives of Oral Biology·Martyn T Cobourne, Paul T Sharpe
Dec 24, 2003·Journal of Dental Research·E MatalovaP T Sharpe

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Citations

Aug 22, 2006·Orthodontics & Craniofacial Research·E MatalováP T Sharpe
Feb 21, 2007·Differentiation; Research in Biological Diversity·Sung-Won ChoHan-Sung Jung
Jan 21, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Irving M ShapiroVickram Srinivas
Jul 6, 2021·Frontiers in Cell and Developmental Biology·John AbramyanMarcela Buchtová

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