PMID: 7536012Dec 1, 1994Paper

Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model

Current Opinion in Immunology
G G SingerA K Abbas

Abstract

Proteins encoded by the fas and fas ligand (fasL) genes are involved in apoptotic cell death in lymphocytes. In this article we review the recent elucidation of the role of the Fas-FasL interactions in the maintenance of tolerance to self antigens and in the homeostatic regulation of lymphocyte clonal expansion, and discuss the mechanisms of autoimmunity in Fas- and FasL-deficient mutant mouse strains.

References

Nov 1, 1992·Journal of Neurobiology·M Driscoll
Jan 1, 1992·Annual Review of Immunology·J J CohenK S Sellins
Jan 1, 1992·Annual Review of Immunology·C C Goodnow
Jan 1, 1992·Immunology Today·Y J LiuI C MacLennan
Jan 1, 1991·Annual Review of Immunology·P L Cohen, R A Eisenberg
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A StrasserA W Harris
Jan 1, 1991·Advances in Immunology·G KroemerC Martínez
Apr 24, 1987·Cell·J W KapplerP Marrack
Dec 1, 1993·The Journal of Experimental Medicine·M R AldersonD H Lynch
Mar 1, 1994·The Journal of Experimental Medicine·T Suda, S Nagata
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·S T JuA Marshak-Rothstein
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M AdachiS Nagata
Apr 1, 1994·The Journal of Experimental Medicine·A M JevnikarL H Glimcher
Oct 1, 1994·European Journal of Immunology·A M GenaroC Martinez
Aug 1, 1994·European Journal of Clinical Investigation·J E TaylorJ A Goodacre
May 1, 1994·Immunology Today·G Kroemer, C Martínez
Apr 29, 1994·Science·K WhiteH Steller
Jan 28, 1994·Cell·J Sprent

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Citations

Jun 1, 1996·Arthritis and Rheumatism·J B Lefkowith, G S Gilkeson
May 5, 2001·Pharmacology & Therapeutics·K SharmaY F Shi
Apr 4, 1998·Journal of Neuroimmunology·Emilio CiusaniAndrea Salmaggi
Jul 17, 1999·Journal of Neuroimmunology·P SacerdoteA E Panerai
Dec 1, 1996·Current Opinion in Immunology·E A TivolA H Sharpe
Jun 14, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ivan D MolanoGary S Gilkeson
Aug 6, 2000·Immunology·E O'FlahertyJ A Kirby
Apr 1, 1996·The Journal of Experimental Medicine·M T EsserV L Braciale
Jun 1, 1996·The Journal of Experimental Medicine·T L WalunasJ A Bluestone
Aug 3, 1999·The Journal of Experimental Medicine·G A RabinovichY Chernajovsky
May 8, 2002·The Journal of Experimental Medicine·Silvia BollandJeffrey V Ravetch
Jul 30, 2008·The Journal of Experimental Medicine·Uwe NiesnerAndreas Radbruch
Jul 13, 2000·Molecular Pathology : MP·S Afford, S Randhawa
Nov 4, 2009·Immunotherapy·Maria C BunielVincent K Tuohy
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·A S VaradhacharyP Salgame
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J DesbaratsM K Newell
Dec 21, 2000·Current Rheumatology Reports· Felipe Flores-Suárez L, D Alarcón-Segovia
Dec 21, 2000·Current Rheumatology Reports·J S Navratil, J M Ahearn
Dec 20, 1999·Japanese Circulation Journal·Y FurukawaS Sasayama
Aug 6, 2002·Journal of Neuroimmunology·Boris SakicHenry Szechtman
Jan 16, 2007·Brain Research Reviews·David A Ballok
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Caigan DuAnthony M Jevnikar
Jul 5, 2005·Expert Opinion on Investigational Drugs·T BrunnerC Mueller
Apr 18, 2015·Arthritis Research & Therapy·Jürgen DiekerJohan van der Vlag
May 18, 2016·The Journal of Clinical Investigation·Jianxun WangMaria I Kontaridis
Jan 20, 1997·The Journal of Experimental Medicine·K J ErbK Rivett
Jan 13, 2015·Scientific Reports·Lidia DaszkiewiczDimitrios Balomenos
Jan 6, 2001·Memórias do Instituto Oswaldo Cruz·G A Rabinovich
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G A RabinovichC E Sotomayor
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G A RabinovichC E Sotomayor

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