Apoptosis in cardiovascular remodeling--effect of medication

Cardiovascular Drugs and Therapy
D deBloisP Hamet

Abstract

In the last decade, apoptosis has emerged as a key determinant of target organ damage in cardiovascular diseases. The suggestion that increased cardiomyocyte apoptosis participates in the etiology of heart failure probably contributed to the negative view of the prevalence of apoptosis in the field of cardiovascular diseases. However, we and others have shown that up-regulation of apoptosis in certain cardiovascular cells may contribute to the beneficial action of antihypertensive drugs on target-organ structure. As an explanation for this apparent discrepancy, the same stimulus, e.g. angiotensin II, can induce apoptosis or stimulate cell growth in different cell types (e.g., cardiomyocytes and fibroblasts, respectively). Using the angiotensin pathway as a paradigm, this review proposes an integrative view of cell growth and cell death regulation in cardiovascular cells in order to illustrate how cell-specific responses to the same stimulus may in part explain the patterns of cell population dynamics during the development and treatment of target organ damage in hypertension.

Citations

Apr 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F Kristek, M Gerová
Oct 30, 2018·Journal of the American Heart Association·Josefin SoppertChristian Stoppe
Mar 20, 2004·Expert Review of Cardiovascular Therapy·María A FortuñoJavier Díez
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ernesto L Schiffrin, Rhian M Touyz
Mar 11, 2005·Canadian Journal of Physiology and Pharmacology·Denis DebloisPavel Hamet
Mar 29, 2005·Molecular and Cellular Biochemistry·Bodh I Jugdutt, Halliday A Idikio
Jun 15, 2011·Cardiovascular Toxicology·Sathish Kumar ManeyC C Kartha
Dec 29, 2020·Cellular Signalling·Alexandra M GarvinTaben M Hale

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