PMID: 9171221Jun 10, 1997Paper

Apoptosis in HIV-infected individuals is an early marker occurring independently of high viremia

AIDS Research and Human Retroviruses
M RothenC Moroni

Abstract

We have analyzed the immunoreactivity of peripheral blood mononuclear cells by determining the proliferative response to four mitogens, one superantigen, and one recall antigen together with the occurrence of activation-induced apoptosis from 213 HIV-1-seropositive individuals from all stages of infection. The expected decline of immunoreactivity observed with time after infection correlated with disease progression and the loss of CD4 cells. Apoptosis was already detectable at the early stages of infection and increased only slightly with disease progression. In analyzing 13 patients with high and low apoptosis rates we observed no correlation to HIV-1 viremia. Our results argue that mitogen-induced apoptosis occurs in both infected and noninfected T cells and can be detected before mitogenic responsiveness is reduced.

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Citations

Jan 1, 2010·Cell Death & Disease·N W Cummins, A D Badley
Apr 2, 1999·Immunology and Cell Biology·A Jaworowski, S M Crowe
Jun 23, 2010·The Journal of Infectious Diseases·Nathan W CumminsAndrew D Badley
Oct 4, 2011·Biochemical and Biophysical Research Communications·Massimiliano AgostiniGerry Melino
May 12, 1998·Clinical Immunology and Immunopathology·T W McCloskeyS Pahwa
Sep 25, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S J ChavanS G Pahwa
May 9, 2000·Memórias do Instituto Oswaldo Cruz·I Neves, M Morgado
Mar 9, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J C WasmuthU Spengler
Feb 19, 2000·Biochemical and Biophysical Research Communications·N YoshinoM Honda

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