Apoptosis in multiple myeloma: therapeutic implications

Apoptosis : an International Journal on Programmed Cell Death
D Chauhan, K C Anderson

Abstract

Apoptosis is the primary means by which most radio- and chemotherapy modalities kill cancer cells, and abnormalities in the apoptotic pathways may contribute to disease pathogenesis of cancer. Multiple Myeloma (MM) is a hematological malignancy which will affect 14,000 new individuals in the United States in 2001 and remains irreversibly fatal despite all available therapies. The current review focuses on the studies of apoptotic and survival signaling pathways in MM cells, which have both identified novel apoptotic and anti-apoptotic proteins and provided targets for novel therapeutics.

Citations

Mar 6, 2003·Reviews in Clinical and Experimental Hematology·Deepak GuptaKenneth C Anderson
Nov 28, 2001·Hematology·W S DaltonJ L Harousseau
Jan 30, 2008·Cell Research·Khandaker Al Zaid Siddiquee, James Turkson
Jul 9, 2003·Immunological Reviews·Teru HideshimaKenneth C Anderson
May 18, 2001·The Journal of Biological Chemistry·D ChauhanK C Anderson
Nov 26, 2002·Hematology·Kenneth C AndersonG David Roodman
Apr 21, 2010·Medical Oncology·Thomas ReskeNikhil C Munshi
Nov 26, 2014·Nature Reviews. Clinical Oncology·Meletios A DimopoulosKenneth C Anderson
Sep 5, 2003·International Journal of Hematology·Dharminder ChauhanKenneth C Anderson
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoko TakebeGuido Tricot
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Teru HideshimaKenneth C Anderson
Aug 7, 2001·Seminars in Hematology·K C Anderson

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