PMID: 9558488Apr 29, 1998Paper

Apoptosis in murine hair follicles during catagen regression

Archives of Dermatological Research
K MatsuoT Hashimoto

Abstract

Catagen hair follicle involution has been reported to involve apoptosis, although the precise mechanism has not been satisfactorily resolved. Previous studies have involved solely morphological or electron microscopical methods. We report here studies on murine hair follicles during the first postnatal hair cycle conducted using the terminal deoxy-nucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) method. Electrophoresis of DNA isolated from the hair follicles of the same animals was carried out in order to confirm the systematic fragmentation of DNA that typifies apoptosis. On day 10, when all the follicles were growing, there was no evidence of staining with TUNEL in the hair bulbs. Electrophoresis similarly did not show characteristic DNA ladders. By day 15, a few positive cells were observed in the hair bulbs and the numbers had increased by day 17 when many positive cells were seen, especially in the lower portions of the follicles. Electrophoresis demonstrated DNA ladders on days 15, 16 and 17, although the DNA ladder on day 15 was less prominent than that on day 17. These studies confirmed that apoptosis, as identified by techniques that measure DNA fragmentation, occurs in the lower regions of hair follicle...Continue Reading

Citations

Jul 27, 1999·Pathology International·T Nakamura
Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Vladimir A Botchkarev, Jiro Kishimoto
May 11, 1999·Journal of Cutaneous Pathology·T Nakamura
Sep 21, 2001·The Journal of Investigative Dermatology·M RobinsonC A Jahoda
Jan 19, 2006·The Journal of Investigative Dermatology·Natalia V BotchkarevaDouglas Shander
Jan 5, 2005·Free Radical Biology & Medicine·Thomas ZulianiMarie-Hélène Ratinaud
Jun 9, 2012·Journal of Theoretical Biology·Yusur Al-NuaimiGerold Baier
Jul 10, 2016·Archives of Dermatological Research·Leilei YangYang Li
Sep 2, 2003·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Vladimir A Botchkarev, Ralf Paus
Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis