PMID: 7544907May 1, 1995Paper

Apoptosis in the central nervous system of developing mouse fetuses from 5-azacytidine-administered dams

Toxicologic Pathology
M M HossainN Goto

Abstract

To determine the effect of 5-azacytidine (5 Az), a cytidine analogue, on the developing fetus, different strains of mice were injected with various doses of the agent, ip, at 11 days of gestation. Light microscopically, severely pyknotic cell death profiles were observed in different layers of the developing brain and spinal cord (central nervous system) on the day after the injection. Electron microscopy of the pyknotic cells revealed the shrinkage of the cell body, to various degrees margination of the nuclear chromatin, condensation of nuclear materials, fragmentation of the affected cells, and, finally, neat "bite-size" bodies engulfed by surrounding normal neuroepithelial cells and macrophage-like cells. DNA fragmentation was detected in the nuclei of the pyknotic cells by an in situ detection method for fragmented DNA ends. These changes were consistent with the criteria of apoptosis.

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jan 1, 1985·Advances in Experimental Medicine and Biology·J J CohenL K Olson
Jan 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·T Yamada, H Ohyama
Jan 1, 1968·Developmental Biology·S L Kauffman, L Herman
Jan 1, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·G Schlüter
Nov 1, 1971·The American Journal of Anatomy·J Langman, M Shimada
May 15, 1968·Experientia·M SeifertováF Sorm
Dec 9, 1982·The New England Journal of Medicine·T J LeyA W Nienhuis
Jul 1, 1984·Archives of Toxicology·W SchmahlH Kriegel
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Apr 1, 1986·Immunology Today·E Duvall, A H Wyllie

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Citations

Feb 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M M HossainN Goto
Dec 14, 2002·Brain Research. Developmental Brain Research·Chao Chuan WangChen Yuan Wen
Oct 23, 1998·Pharmacology & Toxicology·H ForsbergN Welsh
Oct 18, 2002·International Journal of Experimental Pathology·Masaki UenoKunio Doi
Nov 21, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Satoshi FurukawaIzumi Ogawa
Jun 23, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Satoshi FurukawaIzumi Ogawa
Jul 18, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Asok K Dasmahapatra, Ikhlas A Khan
Jun 13, 2012·The Journal of Toxicological Sciences·Kenji TakiTakemi Yoshida
Jul 17, 2008·The Journal of Veterinary Medical Science·Satoshi FurukawaIzumi Ogawa
Oct 30, 2004·Toxicologic Pathology·Satoshi FurukawaIzumi Ogawa
Sep 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rajgopal GovindarajanJashvant D Unadkat

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Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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