Apoptosis in the trophoblast--role of apoptosis in placental morphogenesis

Journal of the Society for Gynecologic Investigation
B Huppertz, J Kingdom

Abstract

Villous trophoblast is the epithelial cover of the placental villous tree and comes in direct contact with maternal blood. The turnover of villous trophoblast includes proliferation and differentiation of cytotrophoblast, syncytial fusion of cytotrophoblast with the overlying syncytiotrophoblast, differentiation in the syncytiotrophoblast, and finally extrusion of apoptotic material into the maternal circulation. In recent years, it has become clear that apoptosis is a normal constituent of trophoblast turnover and the release of apoptotic material does not lead to an inflammatory response of the mother. During preeclampsia there seems to be an altered balance between proliferation and apoptosis of villous trophoblast leading to a dysregulation of the release from the syncytiotrophoblast. The normal apoptotic release may be reduced in favor of a necrotic release. Since apoptosis is still ongoing in the syncytiotrophoblast, a necrotic release of intrasyncytial and partly apoptotic material lead us to call this type of release "aponecrotic shedding." In this situation, cell-free components such as G-actin and DNA freely floating in maternal blood may trigger damage to the maternal endothelium, thereby triggering preeclampsia. Thi...Continue Reading

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A KawakamiP Anderson
Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H ArnholdtU Löhrs
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J G HaddadJ W Sanger
Dec 1, 1983·American Journal of Reproductive Immunology : AJRI·D L EmersonR M Galbraith
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·J L TaupinP Anderson
Jun 1, 1995·Archives of Histology and Cytology·M YasudaY Tsutsumi
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·J G Haddad
Sep 13, 1993·FEBS Letters·B HonoréH Leffers
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·T Fernandes-AlnemriE S Alnemri
Jul 10, 1997·Nature·M IrmlerJ Tschopp
Aug 1, 1997·Trends in Biochemical Sciences·D W Nicholson, N A Thornberry
Dec 9, 1997·Cell·G S Salvesen, V M Dixit
Apr 1, 1994·Journal of the Society for Gynecologic Investigation·N SakuragiJ F Strauss
Feb 14, 1998·The Journal of Cell Biology·Y IshizakiM C Raff
May 23, 1998·Experimental Cell Research·K MoriokaH Takano-Ohmuro
Jul 1, 1998·British Journal of Obstetrics and Gynaecology·M KnightI L Sargent
Nov 24, 1998·Histochemistry and Cell Biology·B HuppertzP Kaufmann
Jan 13, 2000·Trends in Neurosciences·K K Wang
Feb 17, 2000·Trends in Neurosciences·E C GilmoreK Herrup
Mar 31, 2000·Experimental Cell Research·S Nagata
Apr 29, 2000·Journal of the Society for Gynecologic Investigation·F Arechavaleta-VelascoF Vadillo-Ortega

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Citations

Apr 13, 2006·Histochemistry and Cell Biology·Ulrich MieheBerthold Huppertz
Jun 28, 2007·Apoptosis : an International Journal on Programmed Cell Death·Hirofumi YamauchiHiroyuki Nakayama
Nov 28, 2007·Apoptosis : an International Journal on Programmed Cell Death·Hung-Yi WuChiun-Jye Yuan
Nov 6, 2010·Apoptosis : an International Journal on Programmed Cell Death·Alexander E P HeazellIan P Crocker
Jan 19, 2013·Bulletin of Experimental Biology and Medicine·A I ShchyogolevR G Shmakov
Aug 14, 2012·Journal of Molecular Histology·Ling ZhangZhan Zhang
Oct 18, 2013·Human Reproduction Update·Russel J ReiterSergio A Rosales-Corral
Nov 3, 2010·Reproductive Biology and Endocrinology : RB&E·Delphine BenaitreauMarie-Noëlle Dieudonné
Apr 19, 2011·Reproductive Biology and Endocrinology : RB&E·Jayasree SenguptaDebabrata Ghosh
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·E VasilopoulouS-Y Chan
Dec 2, 2005·Journal of Perinatal Medicine·Donna M Neale, Gil Mor
Dec 3, 2013·Progress in Biophysics and Molecular Biology·Berthold HuppertzJayasree Sengupta
Jun 22, 2014·Journal of Reproductive Immunology·Ahmed S NasrMona F Shehata
Nov 13, 2009·Nutrition Reviews·Hairong XuWilliam Fraser
Jul 12, 2007·Seminars in Immunopathology·Berthold Huppertz
Jul 12, 2007·Seminars in Immunopathology·Anurag Kumar GuptaSinuhe Hahn
Apr 25, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jasminka Rešić KararaIvana Kuzmić Prusac
May 20, 2009·The Journal of Physiology·Christina M Scifres, D Michael Nelson
Mar 15, 2013·Journal of Reproductive Immunology·Sien Yee LauLawrence W Chamley
Jan 1, 2013·Pregnancy Hypertension·Satya S PolavarapuChaur-Dong Hsu
Sep 21, 2015·Archives of Gynecology and Obstetrics·Qingwen ZhuJianhua Chen
Mar 2, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Lorenz KuesselCahit Birdir

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