Apoptosis inhibition or inflammation: the role of NAIP protein expression in Hodgkin and non-Hodgkin lymphomas compared to non-neoplastic lymph node.

Journal of Inflammation
Safoura MazroueiMansoor Salehi

Abstract

Inhibitors of Apoptosis (IAP) family play a critical role in apoptosis and inflammatory response. Neuronal Apoptosis Inhibitory Protein (NAIP), as a member of both IAPs and NLR families (NOD-Like Receptor), is a unique IAP harboring NOD (Nucleotide Oligomerization Domain) and LLR (Leucine Rich Repeat) motifs. Considering these motifs in NAIP, it has been suggested that the main function of NAIP is distinct from other members of IAPs. As a member of NLR, NAIP mediates the assembly of 'Inflammasome' for inflammatory caspase activation. Pathologic expression of NAIP has been reported not only in some infectious and inflammatory diseases but also in some malignancies. However, there is no report to elucidate NAIP expression in lymphomatic malignancies. In this study, we examined NAIP protein expression in 101 Formalin-Fixed Paraffin-Embedded blocks including samples from 39 Hodgkin Lymphoma and 23 Non Hodgkin Lymphoma cases in comparison with 39 control samples (30 normal and 9 Reactive Lymphoid Hyperplasia (RLH) lymph nodes) using semi-quantitative immuno-flourecent Staining. NAIP expression was not statistically different in lymphoma samples neither in HL nor in NHL cases comparing to normal samples. However, we evaluated NAIP ex...Continue Reading

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Citations

Apr 29, 2014·Annals of Diagnostic Pathology·Amir Pouya TanhaeiMansoor Salehi
Jan 1, 2014·Pathology Oncology Research : POR·Zsófia UjjLászló Rejtő
Dec 29, 2015·Cellular and Molecular Life Sciences : CMLS·Nidhi Sharma, Sushmita Jha
Feb 1, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Simon D PouwelsMartijn C Nawijn
Sep 28, 2017·Molecular Genetics and Metabolism·Paula Rozenfeld, Sandro Feriozzi

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