PMID: 9647066Jul 1, 1998Paper

Apoptosis is involved in acute cardiac allograft rejection in rats

The Annals of Thoracic Surgery
Y KageyamaY Harada

Abstract

Allograft rejection remains a major obstacle to long-term survival in heart transplantation. Recent studies have demonstrated that apoptotic cell death may occur in acute allograft rejection. The purpose of this study was to determine whether apoptotic cell death is involved in rat cardiac allograft rejection through both the perforin/granzyme pathway and the Fas/Fas ligand (Fas-L) pathway. Groups of Lewis (RT1(1)) rats underwent heterotopic heart transplantation from disparate DA (RT1a) or syngeneic Lewis rats. The cardiac grafts were harvested 1, 3, or 5 days after transplantation and analyzed for apoptotic cell death using DNA nick-end labeling, immunocytochemistry, and electron microscopy. In addition, the expression of granzyme B, perforin, Fas, and Fas-L messenger RNA were analyzed by reverse transcriptase-polymerase chain reaction. Apoptotic cell death of cardiac myocytes was prominent in allografts on day 5 after transplantation. Fas gene transcripts were constitutively expressed in both syngeneic and allogeneic grafts, whereas expression of Fas-L was only upregulated in allografts with ongoing rejection. Granzyme B and perforin gene expression were also upregulated in allografts with ongoing rejection. These results su...Continue Reading

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Citations

Jun 29, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Leora B BalsamRobert C Robbins
Jun 23, 2001·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·A Y WangA E Farnsworth
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Murray H KownRobert C Robbins
Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Murray H KownRobert C Robbins
May 24, 2000·Nuclear Medicine Communications·F G BlankenbergH W Strauss
May 30, 2006·Transplantation·Thor UelandPål Aukrust
Jan 16, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideyuki KondoKazuyuki Shimada
Jul 10, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M H KownR C Robbins
Dec 17, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mark StegallWalter Kremers
Sep 2, 2010·Revista española de cardiología·Carmen CristóbalJuan C Martínez
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L GomezM Ovize
Jan 15, 2002·Cardiology Clinics·R A LockshinZ Zakeri
Jan 15, 2002·Cardiology Clinics·L W MillerB M McManus
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Philip F HalloranR Chris Bleackley
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Olivier RaiskyM Ovize
Aug 18, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Horst FingerhuthThomas H W Stadlbauer

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