PMID: 9192356May 1, 1997Paper

Apoptosis-like cell death in experimentally-induced cryptorchidism in adult mice

The Journal of Veterinary Medical Science
K ItoY Hayashi

Abstract

In order to elucidate the mechanism of germ cell degeneration in experimental cryptorchidism, we examined the testes of adult mice from a morphological standpoint. Adult ICR mice were made cryptorchid either unilaterally or bilaterally. In some mice, testes were surgically replaced back into the scrotum at 2 months after induction of cryptorchidism to observe the regenerative process. Morphological changes of cryptorchid and replaced testes have been studied by light and electron microscopy. Testes were also examined by the TUNEL (TdT-mediated dUTP-biotin nick end labelling) method to evaluate whether the degenerative cells, spermatocytes and spermatids, were dying by apoptosis or by any other process(es). At 8 weeks after the induction of cryptorchidism, the seminiferous epithelium consisted only of Sertoli cells, spermatogonia, and some spermatocytes of early meiotic stages. Soon after the replacement of testes to the scrotum, most of the seminiferous tubules resumed spermatogenic processes. Many degenerating cells, especially the spermatocytes, showed condensation of the nucleus and cytoplasm in cryptorchid testes. Although the cytoplasm was markedly eosinophilic under a light microscope to imply condensation of the cytoplas...Continue Reading

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Citations

Mar 17, 1999·Aging : Clinical and Experimental Research·C J BarnesM Lee
Oct 1, 2005·Pathology Oncology Research : POR·Mehmet DündarHaluk Erol
Oct 4, 2006·International Journal of Andrology·Wieslawa WidlakZdzislaw Krawczyk
May 29, 2012·General and Comparative Endocrinology·Kazuki MaedaSakae Takeuchi
Aug 18, 2005·BJU International·Kenechukwu G OfordemeBarry A Kogan
Jun 7, 2002·The Journal of Urology·Hiroshi TomomasaHiromichi Ishikawa
Nov 25, 2003·The American Journal of Pathology·Reza J RasoulpourKim Boekelheide
Jun 14, 2000·The Journal of Veterinary Medical Science·E KawakamiT Tsutsui
Apr 13, 2007·Biology of Reproduction·Natalia E FurlandMarta I Aveldaño
Mar 30, 2007·The Journal of Biological Chemistry·Natalia E FurlandMarta I Aveldaño
Oct 13, 2006·Urologia Internationalis·Ramazan KarabulutNuri Kale
Feb 28, 2018·BMC Veterinary Research·Giovanna LiguoriNicola Mirabella

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