Apoptosis-mediated immunotoxicity of polychlorinated biphenyls (PCBs) in murine splenocytes

Toxicology Letters
B S YooH M Kim

Abstract

Polychlorinated biphenyls (PCBs) exhibited immunotoxicity on antibody forming response to T-dependent antigen of sheep red blood cells, primary activation of T cells by mixed lymphocyte response, and lymphocyte proliferation induced by various mitogens. These immunosuppressions were related with the loss of lymphocyte viability which was determined by the propidium iodide method, and this death was proven to be linked with apoptosis which showed DNA fragmentation detected by the diphenylamine method and agarose gel electrophoresis. The degree of DNA fragmentation was increased in a dose- and time-dependent manner in PCB-treated splenocytes. In conclusion, it was assumed that apoptosis was attributable to the immunotoxicity of PCBs in murine splenocytes.

References

Jan 1, 1989·International Journal of Immunopharmacology·H TryphonasZ Z Zawidzka
Jun 1, 1989·Toxicology·R J SmialowiczC B Copeland
Aug 1, 1983·Journal of Toxicology and Environmental Health·P A Talcott, L D Koller
Mar 1, 1993·Immunology Today·J J Cohen

❮ Previous
Next ❯

Citations

Apr 1, 2005·Journal of Toxicology and Environmental Health. Part a·Kendra F GoffKeith A Grasman
Jan 5, 2002·Biological & Pharmaceutical Bulletin·S H LeeH M Kim
Dec 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Paola PocarBernd Fischer
Jan 1, 1999·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals· Leonard I Sweet Dora R Passino-Reader Peter G Meier Geneva M Omann
Apr 4, 2015·Toxicology Mechanisms and Methods·Teuta MuratiIvana Kmetič
Sep 20, 2002·The Journal of Toxicological Sciences·Kazuyuki NagamiHiroyoshi Matsumoto
Dec 19, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Seul Min ChoiByung Mu Lee
Apr 13, 2017·Toxicology Mechanisms and Methods·Li TangFeng Chen
Feb 24, 2011·Environmental Toxicology·Bayram YilmazDavid O Carpenter
May 26, 2017·Environmental Monitoring and Assessment·Yunpeng YuRavi Gooneratne
Sep 1, 2009·Toxicological Research·Duck-Jin SaByung-Sun Yoo
Mar 14, 1998·Toxicology and Applied Pharmacology·Z IslamN Sakato
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aziz EftekhariMohammad Hasanzadeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.