Apoptosis of human retina and retinal pigment cells induced by human cytomegalovirus infection

Ophthalmic Research
Shih-Hwa ChiouWen-Ming Hsu

Abstract

Human cytomegalovirus (HCMV) retinitis is the most common ocular opportunistic infection in immunocompromised patients and AIDS. It often leads to blindness if left untreated. The question as to how HCMV infection causes retinal pathogenesis and visual destruction in AIDS patients remains unresolved. To answer the question, by using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling assay, we detected the significant signals of apoptotic cells at the same sites in the HCMV-infected retina of AIDS patients as compared to AIDS patients without HCMV retinitis. In vitro study also revealed apoptosis induced by HCMV infection in human retinal pigment epithelium cells, mediated by activation of caspase 3 and poly(ADP-ribose) polymerase pathway. These results strongly suggest the fundamental role of HCMV-induced apoptosis in mediating cell death in infected human retina and retinal pigment epithelium cells to make severe visual impairment.

Citations

Nov 29, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nikolaos M PharmakakisVassiliki Zolota
Apr 23, 2003·Trends in Microbiology·Martin ScholzJindrich Cinatl
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May 1, 2021·International Journal of Molecular Sciences·Zhongjie YuBin Wang
Aug 8, 2021·International Journal of Molecular Sciences·Xinyan ZhangMing Zhang

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