Apoptosis of lymphocytes in allograft in a rat liver transplantation model induced by resveratrol

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Sheng-Li WuKe-wei Meng

Abstract

To study the effect of resveratrol (RES) on the apoptosis of lymphocytes in allograft in a rat liver transplantation model. Male Sprague-Dawley (SD) rats were selected as donors and male Wistar rats as recipients for a rejection model. The recipients were divided into four groups after orthotopic liver transplantation (OLTx). In the RES A, B, and C groups, RES was given intraperitoneally once a day (25, 50, and 100 mgkg(-1), respectively) after OLTx, whereas in the control group vehicle buffer was given intraperitoneally once a day. The survival period, lymphocytes apoptosis, expressions of Bcl-2/Bax proteins in lymphocytes, and histopathological findings were then compared among these groups. The mean survival period after OLTx in RES C group was significantly longer than that in control group (P < 0.05). On the seventh post-transplant day, the apoptosis index (AI) of lymphocytes in portal area and the positive rate of Bax protein in lymphocytes in RES C group were significantly increased in comparison with those in control group (both P < 0.05), whereas there is no obvious difference in the expression of Bcl-2 protein in lymphocytes between the control group and various drug groups (all P < 0.05), and a histological examinati...Continue Reading

Citations

Sep 5, 2009·The Journal of Clinical Investigation·Jinping ZhangDeyu Fang
Oct 5, 2007·Arhiv za higijenu rada i toksikologiju·Vijayalaxmi RadkarBlase Billack
Oct 3, 2009·International Immunopharmacology·Tan LiLu Ye
Jun 19, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Anupam BishayeeRobb McGory
Aug 15, 2012·Immunological Reviews·Giuseppe MatareseVeronica De Rosa
Jun 3, 2008·Cellular & Molecular Biology Letters·Blase BillackChristelle Adiabouah
May 17, 2012·International Reviews of Immunology·Urban Švajger, Matjaž Jeras
Apr 3, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sahar Hassan-KhabbarValérie Nivet-Antoine
Sep 3, 2019·Archives of Physiology and Biochemistry·Ilknur BingulMujdat Uysal
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Yu-Hsuan HsiehLi-Man Hung

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