Apoptosis of medial smooth muscle cells in the development of saccular cerebral aneurysms in rats

Stroke; a Journal of Cerebral Circulation
S KondoHiroharu Kataoka

Abstract

Using an animal model, we examined the role of apoptosis in the disappearance of medial smooth muscle cells (SMCs) during the development and growth of cerebral aneurysms. Various degrees of cerebral aneurysms were induced in the right anterior cerebral artery-olfactory artery bifurcations in 65 Sprague-Dawley rats with ligation of the left common carotid artery and renal hypertension. We performed in situ end labeling of fragmented DNA with the lesions in 45 rats and electron microscopic study in the other 20 rats. With in situ end labeling of fragmented DNA, 4+/-3 apoptotic medial SMCs were detected in 35 of the 45 bifurcations. Apoptotic SMCs appeared in the medial layer in the "preaneurysm" group, the site speculated to show an aneurysmal change in the near future (6+/-3), and in the media in the "early aneurysm" group, which showed characteristics such as a small depression (5+/-3). In the "progressive aneurysm" group, they appeared more frequently at the aneurysmal neck (3+/-2) than the dome (1+/-1). By electron microscopic study, shrunken medial SMCs exhibiting morphological apoptotic changes such as chromatin condensation and fragmentation of the cytoplasm and nucleus were observed in the preaneurysm and early aneurysm ...Continue Reading

References

Mar 3, 1975·Biochemical and Biophysical Research Communications·Y LegrandL Robert
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jun 1, 1991·American Journal of Respiratory Cell and Molecular Biology·C BoudierJ G Bieth
Feb 1, 1991·Journal of Neurosurgery·H NakataniH Niimi
Jul 1, 1989·Surgical Neurology·C KimF Hazama
Mar 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O SkalliL Orci
Sep 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J AndoA Kamiya
Dec 1, 1987·Journal of Neurosurgery·N HashimotoF Hazama
Sep 1, 1971·The Journal of Pathology·J F Kerr
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Jan 1, 1981·Methods in Enzymology·A J Barrett
Apr 15, 1994·Cancer·J F KerrB V Harmon
Sep 1, 1993·Molecular Biology of the Cell·J E MeredithM A Schwartz

❮ Previous
Next ❯

Citations

Jan 18, 2012·Acta Neuropathologica·Juhana FrösenJuha Hernesniemi
Oct 15, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·David L PennE Sander Connolly
Aug 15, 2000·Surgical Neurology·S Inci, R F Spetzler
Feb 27, 2004·Surgical Neurology·Yasuhiro OhashiHideaki Nukui
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S M ArribasJ C McGrath
Dec 1, 2007·Clinical and Experimental Pharmacology & Physiology·Wei ZhangDing-Feng Su
Dec 3, 2008·Journal of Biomechanical Engineering·Martin Kroon, Gerhard A Holzapfel
Jun 16, 2012·Journal of Neurointerventional Surgery·Christine DingMichael Chen
Sep 29, 2009·Annual Review of Fluid Mechanics·Daniel M SforzaJuan Raul Cebral
May 3, 2008·Stroke; a Journal of Cerebral Circulation·Ling GaoHui Meng
Jun 9, 2006·Neurological Research·Tomoki HashimotoWilliam L Young
Dec 1, 2009·Journal of Neurosurgery·Alexander M NixonBauer E Sumpio
Oct 27, 2009·Journal of Neurosurgery·Tomohiro AokiNobuo Hashimoto
Oct 19, 2010·Journal of Neurosurgery·Hui MengJ Mocco
Dec 16, 2004·Journal of Neurosurgery·Luigi PentimalliGiulio Maira
Apr 7, 2007·Journal of Neurosurgery·Nobutake SadamasaNobuo Hashimoto
Dec 11, 2013·Translational Stroke Research·Robert M StarkeAaron S Dumont
Dec 11, 2013·Translational Stroke Research·Koji Hosaka, Brian L Hoh
Mar 29, 2012·Computational and Mathematical Methods in Medicine·Woowon Jeong, Kyehan Rhee
Apr 18, 2014·Journal of Neuroinflammation·Robert M StarkeAaron S Dumont
Mar 19, 2014·Journal of Neurosurgery·Toshihiro YokoiKazuhiko Nozaki
Sep 15, 2009·AJNR. American Journal of Neuroradiology·R KadirvelD F Kallmes
Feb 5, 2010·Expert Opinion on Therapeutic Targets·Tomohiro Aoki, M Nishimura
May 21, 2015·International Journal of Molecular Sciences·Jenny B LinCraig J Goergen
Nov 8, 2015·World Neurosurgery·Amin AdibiAlim Mitha
Aug 12, 2014·Journal of Neuropathology and Experimental Neurology·Yue-Qi ZhuYing-Sheng Cheng
Jan 24, 2012·Neurología : publicación oficial de la Sociedad Española de Neurología·N M Muñoz-GuillénA Cano-Sánchez
Feb 17, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julian CahillJohn H Zhang
Jul 19, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Muhammad S AliAaron S Dumont
Jul 12, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nohra ChalouhiAaron S Dumont
Nov 26, 2008·Journal of Theoretical Biology·Martin Kroon, Gerhard A Holzapfel
May 8, 2007·Journal of Theoretical Biology·Martin Kroon, Gerhard A Holzapfel
Apr 14, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Fuyou GuoChao You
Feb 2, 2010·Brain Research·Naoto KimuraAkira Takahashi
Jun 30, 2011·IEEE Transactions on Bio-medical Engineering·Harvey HoPeter J Hunter
Mar 11, 2006·Journal of Biomechanics·I ChatziprodromouY Ventikos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.