Apoptosis of neutrophils

Acta Haematologica
N A MaianskiD Roos


Regulation of the neutrophil life span by apoptosis provides a fine balance between their function as effector cells of host defense and a safe turnover of these potentially harmful cells. Alterations of neutrophil apoptosis are associated with a number of diseases. As do other cell types, neutrophils possess components of both extrinsic and intrinsic apoptotic routes. The intrinsic pathway of apoptosis seems to be of major importance in neutrophils since they are programmed for a rapid spontaneous cell death. However, in neutrophils this mechanism of apoptosis has special features, probably due to peculiarities of neutrophil mitochondria, which are believed to be a core regulator of intrinsic cell death. A better understanding of mechanisms underlying neutrophil cell death would help to understand neutrophil physiology and contribute to the search of new approaches for handling of pathology related to disturbances in neutrophil apoptosis and also increase our knowledge of inflammation in general.


Feb 13, 2008·Inflammatory Bowel Diseases·Serena CatarziTeresa Iantomasi
May 30, 2009·Archivum Immunologiae Et Therapiae Experimentalis·E JabłońskaJ Jabłoński
Aug 12, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tobi HigoJohn K Jackson
Sep 17, 2009·Molecules and Cells·So Youn Kim, Yun Soo Bae
Mar 26, 2010·Apoptosis : an International Journal on Programmed Cell Death·Luciana Dini
May 16, 2013·Chinese Journal of Integrative Medicine·Chun-Xiao WuJing-Chun Zhang
May 15, 2013·Trends in Immunology·B GeeringHans-Uwe Simon
Jun 4, 2011·Cell Death and Differentiation·B Geering, H-U Simon
Nov 10, 2010·Cell Research·Quinten RemijsenPeter Vandenabeele
Jul 9, 2005·Critical Care Medicine·Matthias TurinaHiram C Polk
Dec 10, 2009·The Journal of Trauma·Chika KawasakiIrshad H Chaudry
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
Sep 28, 2010·American Journal of Respiratory Cell and Molecular Biology·Larissa DyugovskayaLena Lavie
Nov 10, 2006·Critical Care : the Official Journal of the Critical Care Forum·Léa FialkowGregory P Downey
Jan 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Adnana Paunel-GörgülüTim Lögters
Jun 17, 2008·Journal of Leukocyte Biology·Munetaka Ozeki, John E Shively
Oct 20, 2006·International Journal of Hematology·B J van RaamT W Kuijpers
Jan 15, 2008·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Jerard Kneifati-HayekRita Bellevue
Sep 17, 2010·Molecular Medicine·Suhail AkhtarMashkoor A Choudhry
Jan 1, 2009·Folia Histochemica Et Cytobiologica·Ewa Jablonska, M Garley
Jan 31, 2014·Indian Journal of Clinical Biochemistry : IJCB·Saba KhanPradyumna K Mishra
Sep 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daocheng ZhuHongbo R Luo
Oct 17, 2007·Médecine sciences : M/S·Arpita ChakravartiPatrice E Poubelle
Apr 10, 2010·Veterinary Immunology and Immunopathology·Anja SipkaHans-Joachim Schuberth
Oct 31, 2009·Toxicon : Official Journal of the International Society on Toxinology·Quinten RemijsenJean Willems
Jun 3, 2008·Cytokine & Growth Factor Reviews·Shigekazu Nagata
Aug 30, 2005·Annals of the New York Academy of Sciences·André P van RossumCees G M Kallenberg
Oct 11, 2007·American Journal of Hematology·Hongbo R Luo, Fabien Loison
Sep 25, 2008·Phytotherapy Research : PTR·Małgorzata Zielińska-PrzyjemskaWłodzimierz Grajek
Apr 2, 2011·Neuropathology and Applied Neurobiology·D J ChewP J Shortland
Feb 3, 2005·International Immunopharmacology·John J Haddad, Hisham L Harb
May 3, 2006·Journal of Immunological Methods·Matthew J Cotter, Daniel A Muruve
Aug 17, 2005·The International Journal of Biochemistry & Cell Biology·Petr Jezek, Lydie Hlavatá
Jun 10, 2014·Cellular & Molecular Immunology·Flavia S LakschevitzMichael Glogauer
Aug 19, 2016·Frontiers in Physiology·Isabela HenriquesPatricia R M Rocco
Dec 17, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·Stewart R CarterElizabeth J Kovacs
Mar 27, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Balu K ChackoVictor M Darley-Usmar
Oct 12, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Maowen HuH Hank Simms
Dec 20, 2007·Chirality·Małgorzata Zielińska-PrzyjemskaJoanna Klaczyńska
Mar 25, 2010·The Korean Journal of Parasitology·Hyun-Ouk SongJae-Sook Ryu
Oct 12, 2018·Biochemical Society Transactions·Abel AngMargreet C M Vissers
Dec 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yishay OrrLeonard Kritharides
Mar 14, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kathleen A StringerChristopher C Franklin
Sep 22, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ilya GukovskyStephen J Pandol
Apr 16, 2005·Clinical Science·Daniel D MelleyGregory J Quinlan
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adnana Paunel-GörgülüMartin Scholz
Apr 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katsunari KinaKazuhisa Iwabuchi
Aug 4, 2012·Journal of Applied Physiology·Frank C MoorenKarsten Krüger
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carole ElbimJerome Estaquier
Dec 19, 2020·Intensive Care Medicine Experimental·Xiaomin ZhangClair Hartmann

Related Concepts

Neutrophil Band Cells
Apoptosis, Intrinsic Pathway

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis