Apoptosis of phagocytic cells induced by Candida albicans and production of IL-10

FEMS Immunology and Medical Microbiology
Thaís H GasparotoIonice Felipe

Abstract

Macrophages co-incubated with Candida albicans strain CR1 in vitro showed early signs of apoptosis, but evolved to necrosis after 2 h. In this study, we investigated whether strain CR1 caused apoptosis or necrosis of macrophages after its inoculation into mice peritoneal cavity, and whether this correlated with the secretion of IL-10. Peritoneal macrophages from mice that received an inoculum of C. albicans CR1 showed signs of apoptosis and necrosis from 30 min to 2 h afterwards, whereas heat-killed C. albicans did not cause those effects. IL-10 production was low during the first 6 h post-infection, when macrophages predominated in the peritoneal exudate, whereas its higher production after 24 h correlated with an increase of neutrophils in the exudate. Treatment of CR1 with pepstatin (an inhibitor of proteinases) prevented the process of apoptosis and significantly reduced IL-10 production, suggesting that the increased production of IL-10 was caused by processes occurring during the initial phase of infection, such as apoptosis, necrosis and uptake of death cells.

References

Jan 1, 1991·Annual Review of Microbiology·J E Cutler
Oct 1, 1986·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M Ghannoum, K Abu Elteen
Mar 1, 1995·Infection and Immunity·H KaminishiY Hagihara
Jan 1, 1994·American Journal of Nephrology·C MichelF Mignon
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·A LouieR P Smith
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S J GoldieF O Finkelstein
Dec 6, 1997·Nature·R E VollI Girkontaite
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·P M HensonV A Fadok
Oct 3, 2001·The Journal of Clinical Investigation·V A FadokP M Henson
Nov 16, 2001·Seminars in Immunology·V A Fadok, G Chimini

❮ Previous
Next ❯

Citations

Mar 31, 2009·Immunity & Ageing : I & a·Thaís Helena GasparotoVanessa Soares Lara
Dec 8, 2009·Journal of Periodontology·Valéria GelaniAna Paula Campanelli
Dec 17, 2008·Future Microbiology·Rosalía Diez-Orejas, Elena Fernández-Arenas
Apr 20, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Satsuki KatoYasushi Furuichi
Aug 7, 2009·The Journal of Sexual Medicine·Lúcia Alves da Silva LaraAna Carolina Japur de Sá Rosa-E-Silva
Dec 21, 2010·Revista iberoamericana de micología·Gioconda San-Blas, Eva Burger
Jan 9, 2007·Experimental and Molecular Pathology·Akiko Ishida-OkawaraKazuo Suzuki
Jul 29, 2010·Journal of Oral Rehabilitation·T H GasparotoV S Lara
Nov 22, 2011·FEMS Immunology and Medical Microbiology·Paula Galdino Cardin de CarvalhoIonice Felipe
Mar 20, 2010·FEMS Immunology and Medical Microbiology·Thais Herrero GeraldinoKamila Landucci Bonifácio
Oct 31, 2009·Memórias do Instituto Oswaldo Cruz·Iván Hernández-CañaveralMiguel Domínguez-Hernández
Dec 3, 2009·Immunopharmacology and Immunotoxicology·Ken-ichiro InoueNaohito Ohno
May 27, 2009·Medical Mycology·Venessa TessarolliAna Paula Campanelli
Aug 20, 2019·Cellular Microbiology·Doureradjou PeroumalNarottam Acharya
Feb 23, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hao WuJordan Tang
May 15, 2010·Medical Mycology·Thaís Helena GasparotoAna Paula Campanelli
Nov 26, 2015·Mycopathologia·Danielle Cardoso Geraldo MaiaIracilda Zeppone Carlos
Jun 5, 2021·Cellular Microbiology·Mariana BlagojevicJulian R Naglik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.