Apoptosis: one of the mechanisms that maintains unresponsiveness of the intestinal mucosal immune system

The Journal of Immunology : Official Journal of the American Association of Immunologists
P BuL Qiao

Abstract

Intestinal mucosa is constantly exposed to environmental AGS: Activation of lamina propria (LP) T cells by luminal Ags may lead to the production of inflammatory cytokines and subsequent mucosal inflammation and tissue damage. However, in normal circumstances, LP T cells do not respond to antigenic stimulation. The mechanisms of this unresponsiveness in healthy subjects are not fully understood. In this study, we found by in vivo analysis that, except for T cells in lymph nodules of the mucosa, 15% of LP T cells underwent apoptosis in normal individuals. In contrast, there was a marked reduction in apoptosis of LP T cells in patients with inflammatory bowel disease (Crohn's disease and ulcerative colitis) and those with specific colitis. Our findings suggest that apoptosis might be a mechanism that turns off mucosal T cell responses to environmental Ags in healthy subjects, and resistance to apoptosis could be an important cause of mucosal immune dysregulation and tissue inflammation in colitis.

References

Apr 1, 1992·International Immunology·J Xu-AmanoJ R McGhee
Dec 1, 1991·Gastroenterology·L QiaoS C Meuer
Sep 1, 1993·Gastroenterology·L QiaoS C Meuer
Dec 1, 1996·The Journal of Clinical Investigation·M BoirivantW Strober
Dec 1, 1996·European Journal of Immunology·K BonhagenJ Reimann
Jul 3, 1998·Gastroenterology·C Fiocchi
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z LiuJ L Ceuppens

❮ Previous
Next ❯

Citations

Dec 18, 2002·Annals of the New York Academy of Sciences·Jan M H Van Den BrandeSander J H Van Deventer
Oct 4, 2005·Nature Reviews. Immunology·Ashley T Haase
Oct 4, 2006·Journal of Pineal Research·Emanuela MazzonSalvatore Cuzzocrea
Aug 5, 2009·World Journal of Gastroenterology : WJG·Walid Ben AleyaYousr Gorgi
Jan 1, 2010·Clinical and Translational Gastroenterology·Venkatesh PonemoneRaja Fayad
Aug 9, 2002·Journal of Gastroenterology and Hepatology·Michael C Grimm
Oct 13, 2006·Current Opinion in Gastroenterology·Elke Cario
May 8, 2008·Medicine and Science in Sports and Exercise·Paul A Spagnuolo, Laurie Hoffman-Goetz
Jan 7, 2015·World Journal of Gastroenterology : WJG·Fabiany da Costa GonçalvesAna Helena Paz
Aug 18, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Suprabha Suresh NayakKapaettu Satyamoorthy
May 11, 2004·Journal of Applied Physiology·L Hoffman-GoetzJ Guan
Feb 2, 2008·World Journal of Gastroenterology : WJG·Alper AkcanYucel Aritas
Oct 5, 2010·Tissue Antigens·C GuoD P Jewell
Jun 18, 2011·Pathology Oncology Research : POR·Laszlo BeneAndras Kristof Fulop
Apr 18, 2012·Journal of Gastroenterology and Hepatology·Clover Ching Man WongChi Hin Cho
Apr 21, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mary A ZimmermanKebin Liu
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T D Eaves-PylesR B Pyles
May 24, 2007·Parasite Immunology·M DoligalskaN Drela
Feb 11, 2005·Current Opinion in Gastroenterology·Daniël W Hommes, Sander J H van Deventer
Jul 2, 2003·Journal of Leukocyte Biology·Rachid MarhabaMargot Zöller
Sep 25, 2004·Canadian Journal of Physiology and Pharmacology·S Marra, L Hoffman-Goetz
Jun 28, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Thomas T MacDonaldJohn N Gordon
Jun 6, 2003·Journal of the American Academy of Dermatology·David James Najarian, Alice B Gottlieb
Jun 14, 2003·Gastroenterology·Jan M H Van den BrandeSander J H van Deventer
Sep 17, 2021·Journal of Crohn's & Colitis·Roger SuauJosep Manyé

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Alimentary Pharmacology & Therapeutics
Francesco Pallone, Giovanni Monteleone
Annals of Allergy
C P Braegger, Thomas T MacDonald
The Journal of Immunology : Official Journal of the American Association of Immunologists
S L PenderThomas T MacDonald
The Journal of Immunology : Official Journal of the American Association of Immunologists
C S ProbertR S Blumberg
© 2021 Meta ULC. All rights reserved