PMID: 9188634Jul 1, 1997Paper

Apoptosis plays an important role in experimental rabies virus infection

Journal of Virology
A C Jackson, J P Rossiter

Abstract

Cultured rat prostatic adenocarcinoma (AT3) cells infected with the challenge virus standard (CVS) strain of fixed rabies virus showed characteristic morphologic features of apoptosis, evidence of oligonucleosomal DNA fragmentation, and expression of the Bax protein. CVS-infected Bcl-2-transfected AT3 cells did not demonstrate these features. Adult ICR mice inoculated intracerebrally with CVS showed morphologic changes of apoptosis, DNA fragmentation, and increased Bax expression in neurons, with changes most marked in the hippocampus and cerebral cortex. Ultrastructurally, some neurons demonstrated morphologic features more typical of necrosis. These studies provide evidence that apoptosis plays an important role in the pathogenesis of rabies virus infection.

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Citations

Sep 10, 2003·International Reviews of Immunology·Jillian M Licata, Ronald N Harty
Dec 1, 2009·Nature Reviews. Microbiology·Matthias J SchnellAmy Papaneri
Aug 23, 2016·Viruses·Terence P Scott, Louis H Nel
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Nov 30, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A C Jackson
Apr 7, 2009·The Journal of Veterinary Medical Science·Daisuke KojimaToshifumi Oyamada
Mar 27, 2010·The Journal of Veterinary Medical Science·Daisuke KojimaSatoshi Inoue
Jul 10, 2010·PLoS Pathogens·Pranav DanthiTerence S Dermody
Sep 27, 2013·Journal of Virology·Andrea J PruijssersTerence S Dermody
Sep 12, 2013·SpringerPlus·Kazuyo SenbaAkira Nishizono
Aug 9, 2016·Annual Review of Virology·Pranav Danthi
Jun 10, 2004·The Journal of Veterinary Medical Science·Taekyun ShinHelen Acland
Jul 7, 2009·Future Virology·Bernhard DietzscholdMatthias Schnell
Apr 5, 2005·Journal of Neurovirology·Zhen F Fu, Alan C Jackson
Mar 7, 2008·Journal of Virology·Alireza GholamiHervé Bourhy
Jun 11, 1999·Journal of Virology·S GirardB Blondel
Sep 20, 2005·Virus Research·Małgorzata KrzyzowskaMarek Niemiałtowski
Sep 29, 2011·Journal of Proteome Research·Natthapaninee ThanomsridetchaiVisith Thongboonkerd

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