PMID: 8939562DOI: 10.1016/s0960-9822(02)70706-9Oct 1, 1996Paper
Apoptosis: telling cells their time is up
Current Biology : CB
S Nagata
Abstract
Ligand engagement by the receptor Fas leads to apoptosis. A clue to how this happens comes from the discovery that ligand binding leads to recruitment to Fas of a protease, homologous to interleukin-1 beta converting enzyme, likely to initiate a proteolytic cascade that drives apoptosis.
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