Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure

Liver International : Official Journal of the International Association for the Study of the Liver
Lars P BechmannAli Canbay

Abstract

Cell death is known to play a crucial role in liver diseases. We compared the clinical courses of two cases of liver failure of different origins correlated with the extent of cell death (apoptosis and/or necrosis), measured in the patient's blood. Patient 1 was admitted with acute liver failure following acetaminophen intoxication. Intravenous therapy with acetylcysteine was performed. The percentage of apoptotic cell death measured by M30 was three times higher than normal and the overall cell death measured by M65 was more than 30 x higher than normal. High levels of aminotransferases were detected, indicating high rates of necrosis. M30 and M65 values rapidly returned to normal levels, while the liver function test (LFT) levels decreased with latency. Patient 2 was admitted with acute-on-chronic liver failure with known liver fibrosis. M30 values were 16 x higher than normal. In contrast, M65 values were lower than in the first case. This time, no movement in M30 levels was seen until the M30 levels rapidly increased indicating the inevitable death of the patient, while LFTs did not change. These results indicate the role of M30 and M65 immunoexpression as markers for functioning liver cell mass, capacity for recovery and t...Continue Reading

References

Aug 1, 1989·Gastroenterology·J G O'GradyR Williams
Jul 31, 1993·Lancet·J G O'GradyR Williams
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H BantelK Schulze-Osthoff
Jan 29, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hartmut JaeschkeJohn J Lemasters
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ali CanbayGregory J Gores
Dec 4, 2003·Journal of Hepatology·Ariel E FeldsteinGregory J Gores
Mar 23, 2004·Annals of the New York Academy of Sciences·George E N KassRichard H Hinton
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anne M LarsonUNKNOWN Acute Liver Failure Study Group

❮ Previous
Next ❯

Citations

May 9, 2012·World Journal of Gastroenterology : WJG·Sahar K HegazyAkira Yagi
Mar 8, 2014·World Journal of Gastroenterology : WJG·Su-Jun ZhengZhong-Ping Duan
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xandra VolkmannHeike Bantel
Jan 1, 2013·ISRN Hepatology·Kewei Wang, Bingliang Lin
Jan 29, 2016·World Journal of Gastroenterology : WJG·Manuel Mendizabal, Marcelo Oscar Silva
Feb 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel J AntoineB Kevin Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis