Apoptosome formation and caspase activation: is it different in the heart?

Journal of Molecular and Cellular Cardiology
Lech Czerski, G Nuñez

Abstract

Apoptosis is a form of cell death which utilizes energy resources to dismantle and remove cells in an orderly or programmed fashion. It plays an essential role in establishing normal embryonic development, maintaining adult tissue homeostasis and contributes to a variety of human diseases including certain pathological processes in the heart. Apoptosis is mediated by a distinct biochemical pathway that is conserved in multicellular organisms. Signaling for apoptosis is initiated from outside the cell (extrinsic or death receptor pathway) or from inside the cell (intrinsic or mitochondrial pathway). In both pathways, signaling results in the activation of a family of cysteine proteases, named caspases, that act in a proteolytic cascade to dismantle and remove the dying cell. The activation of the intrinsic death pathway involves the release of cytochrome c from the mitochondria and formation of the apoptosome, a catalytic multiprotein platform that activates caspase-9. There is evidence that the mitochondrial pathway is involved in ischemia-induced myocyte apoptosis in the heart. Diminished expression of pro-apoptotic factors and/or expression of certain inhibitors of the apoptosome may raise the threshold for apoptosis in long-...Continue Reading

References

Jan 1, 1991·Archives of Toxicology·D J FawthropD S Davies
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D L Vaux
Jan 21, 1997·Circulation·A SarasteL M Voipio-Pulkki
Feb 7, 1997·Cell·S Nagata
Jul 10, 1997·Nature·M IrmlerJ Tschopp
Aug 15, 1997·The Biochemical Journal·G M Cohen
Jan 7, 1998·The Journal of Cell Biology·K G WolterR J Youle
Feb 28, 1998·The Journal of Biological Chemistry·M MuzioV M Dixit
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·T KosekiG Núñez
Jun 13, 1998·Biochemistry·J D CorteseC R Hackenbrock
Jul 4, 1998·Molecular Cell·S M SrinivasulaE S Alnemri
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Oct 9, 1998·The Journal of Biological Chemistry·H R StennickeG S Salvesen
Dec 5, 1998·The Journal of Biological Chemistry·Y HuG Núñez
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NaritaY Tsujimoto
Feb 17, 1999·Genes & Development·Q L Deveraux, J C Reed
Mar 20, 1999·The Journal of Biological Chemistry·H R StennickeG S Salvesen
Apr 23, 1999·The Journal of Biological Chemistry·R Malhotra, F C Brosius
Jun 11, 1999·The Journal of Biological Chemistry·A SalehE S Alnemri
Nov 5, 1999·Structure·G S Salvesen
Dec 1, 1999·Cell Death and Differentiation·D W Nicholson
Jan 5, 2000·Genes & Development·J Rodriguez, Y Lazebnik
Feb 1, 2000·Journal of Molecular and Cellular Cardiology·D de MoissacL A Kirshenbaum
Feb 11, 2000·Annals of the New York Academy of Sciences·E JacototG Kroemer
Mar 21, 2000·Journal of Molecular and Cellular Cardiology·B FreudeJ Schaper
Apr 4, 2000·Journal of Cardiac Failure·P M Kang, S Izumo

❮ Previous
Next ❯

Citations

Jan 28, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Zhen CheRui Ding
Apr 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Jessica A SipkensHans W M Niessen
Apr 9, 2008·Physiological Reviews·Elizabeth Murphy, Charles Steenbergen
Dec 10, 2013·International Journal of Molecular Sciences·Nurul Husna ShafieAshok Kumar Pandurangan
Oct 7, 2009·Antioxidants & Redox Signaling·Laura V PappKum Kum Khanna
Mar 18, 2006·Apoptosis : an International Journal on Programmed Cell Death·C MeischlH W M Niessen
Dec 22, 2015·Journal of Molecular and Cellular Cardiology·Zuyue SunEugene A Konorev
Oct 6, 2005·Journal of Cellular and Molecular Medicine·Janice L V ReeveAfshin Samali
Jan 10, 2013·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Xiaoni LiuXiaoxin Zhu
Apr 13, 2010·Cytokine·Dhan V KalvakolanuSudhakar Kalakonda
Oct 24, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Ismail Adam ArbabSiddig Ibrahim Abdelwahab
Jun 22, 2016·Life Sciences·Munthipha KhamphioNatthida Weerapreeyakul
Jan 10, 2017·PloS One·Rui-Ting ChenYun-Gen Miao
Apr 4, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xue-Jiao ZhangFeng-Ying Huang
Mar 13, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ying LiuZhibo Xiao
Mar 18, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Ling XueGunnar Engström
May 8, 2007·The Journal of Biological Chemistry·Thanh H TranNanette H Bishopric
Dec 23, 2011·The Journal of Veterinary Medical Science·Kankanam Gamage Sanath UdayangaHiroshi Kitagawa
May 10, 2008·The Biochemical Journal·Vilmante Borutaite
Jan 7, 2017·BioMed Research International·Yan-Ren LinWen-Liang Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.