PMID: 9537470Apr 16, 1998Paper

Apoptotic bodies: a consistent morphologic feature of endocervical adenocarcinoma in situ

The American Journal of Surgical Pathology
C V Biscotti, W R Hart

Abstract

To evaluate the occurrence of apoptotic bodies in endocervical adenocarcinoma in situ (AIS) and investigate the relationship of apoptosis to mitotic activity, we performed counts of apoptotic bodies and mitotic figures in 43 patients with AIS and in a comparable control group with nonneoplastic endocervical glandular epithelium. The ages of the patients with AIS ranged from 27 to 74 years (mean = 40). Mitotic figures were present in all AIS cases, and apoptotic bodies were seen in all but two extremely small lesions. In 28 AIS cases in which lesions were large enough to count 10 consecutive high-power fields (HPF), counts of apoptotic bodies ranged from 1 to 36/10 HPF (mean and median = 16), and counts of mitotic figures ranged from 1 to 53 mitotic figures/10 HPF (mean and median = 18). Counts of apoptotic bodies correlated directly with counts of mitotic figures. The ages of the 28 control patients ranged from 32 to 56 years (mean = 43). Counts of apoptotic bodies in the control cases ranged from 0 to 10 per case (mean = 1.1). Apoptotic bodies were present in only 13 (46%) control cases. The highest counts in these cases ranged from 1 to 6 apoptotic bodies/10 HPF (mean = 2.3). Mitotic figures were present in only 4 (14%) contr...Continue Reading

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Citations

Dec 24, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Olga B IoffeSteven G Silverberg
Mar 27, 2003·The American Journal of Surgical Pathology·Olga B IoffeSteven G Silverberg
Aug 18, 1999·Diagnostic Cytopathology·N J Mulvany, V Surtees
Mar 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Suzuko MoritaniTakanori Hattori
Dec 24, 2003·The Cancer Journal·Steven G Silverberg, Olga B Ioffe
Dec 12, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Rouba Ali-FehmiSuzanne M Jacques
Jul 8, 2000·American Journal of Clinical Pathology·C M Abramovich, R A Prayson
Jan 10, 2002·Diagnostic Cytopathology·Sarah J LundeenMichael W Stanley
Jun 3, 2020·Advances in Anatomic Pathology·Simona StolnicuW Glenn McCluggage

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