Apoptotic bodies as a morphological feature in serous ovarian carcinoma: correlation with nuclear grade, Ki-67 and mitotic indices

Pathology, Research and Practice
Hermann Brustmann

Abstract

This study evaluated the relation of apoptosis with mitotic activity, Ki-67 indices, and nuclear and architectural grades in serous ovarian carcinoma. Apoptotic body (ABI) and mitotic indices (MI) were obtained by examining hematoxylin and eosin-stained sections from 35 serous ovarian carcinomas for apoptotic bodies and mitotic figures. ABI and MI were reported as the number of apoptotic bodies, and mitotic figures and immunostaining for Ki-67, respectively, as positive cells in 1000 cells. Nuclear grade was determined as grade 1 [n = 11], grade 2 [n = 13], and grade 3 [n = 11] according to recently defined criteria. There was a significant correlation between Ki-67 indices and ABI (p < 0.0001), Ki-67 and MI (p < 0.0001), as well as between MI and ABI (p < 0.0001). ABI increased with nuclear grade (p < 0.0001) and the type of the histological differentiation pattern (from glandular to papillary and solid architectural patterns) (p < 0.0001). Apoptosis, quantitated by ABI, is positively correlated with proliferation, thereby constituting a factor in the regulation of tumor growth of serous ovarian carcinomas. The positive correlation between ABI and increasing nuclear grade, mitotic activity, and architectural growth pattern may...Continue Reading

References

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Citations

Sep 12, 2006·Pathology, Research and Practice·Hermann Brustmann
Mar 2, 2012·Gynecologic and Obstetric Investigation·Tomasz BanasOliwia Grabowska
Sep 16, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Tomasz BanasJoanna Cielecka-Kuszyk
Mar 23, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hermann Brustmann
Dec 31, 2002·The Journal of Biological Chemistry·Yingchang MiPaula J Bates
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amir A JazaeriJeff Boyd

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis